Mechanisms and prevention of UV‐induced melanoma
A Sample, YY He - Photodermatology, photoimmunology & …, 2018 - Wiley Online Library
Melanoma is the deadliest form of skin cancer and its incidence is rising, creating a costly
and significant clinical problem. Exposure to ultraviolet (UV) radiation, namely UVA (315 …
and significant clinical problem. Exposure to ultraviolet (UV) radiation, namely UVA (315 …
UV-induced molecular signaling differences in melanoma and non-melanoma skin cancer
F Liu-Smith, J Jia, Y Zheng - Ultraviolet light in human health, diseases …, 2017 - Springer
There are three major types of skin cancer: melanoma, basal cell carcinoma (BCC) and
squamous cell carcinoma (SCC). BCC and SCC are often referred to as non-melanoma skin …
squamous cell carcinoma (SCC). BCC and SCC are often referred to as non-melanoma skin …
A PGC1α-mediated transcriptional axis suppresses melanoma metastasis
C Luo, JH Lim, Y Lee, SR Granter, A Thomas… - Nature, 2016 - nature.com
Melanoma is the deadliest form of commonly encountered skin cancer because of its rapid
progression towards metastasis,. Although metabolic reprogramming is tightly associated …
progression towards metastasis,. Although metabolic reprogramming is tightly associated …
Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53
A Viros, B Sanchez-Laorden, M Pedersen, SJ Furney… - Nature, 2014 - nature.com
Cutaneous melanoma is epidemiologically linked to ultraviolet radiation (UVR), but the
molecular mechanisms by which UVR drives melanomagenesis remain unclear,. The most …
molecular mechanisms by which UVR drives melanomagenesis remain unclear,. The most …
BRAFV600E restructures cellular lactylation to promote anaplastic thyroid cancer proliferation
X Wang, T Ying, J Yuan, Y Wang, X Su… - Endocrine-related …, 2023 - erc.bioscientifica.com
Anaplastic thyroid cancer (ATC) is a rare but fatal cancer with BRAF mutation ranging from
30 to 50%. Histone lysine lactylation represents a novel epigenetic mark that translates …
30 to 50%. Histone lysine lactylation represents a novel epigenetic mark that translates …
CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma
AS McNeal, K Liu, V Nakhate, CA Natale, EK Duperret… - Cancer discovery, 2015 - AACR
Deletion of the entire CDKN2B–CDKN2A gene cluster is among the most common genetic
events in cancer. The tumor-promoting effects are generally attributed to loss of CDKN2A …
events in cancer. The tumor-promoting effects are generally attributed to loss of CDKN2A …
Molecular regulation of UV‐induced DNA repair
Ultraviolet (UV) radiation from sunlight is a major etiologic factor for skin cancer, the most
prevalent cancer in the United States, as well as premature skin aging. In particular, UVB …
prevalent cancer in the United States, as well as premature skin aging. In particular, UVB …
H3K27me3-mediated PGC1α gene silencing promotes melanoma invasion through WNT5A and YAP
Oncogene-targeted and immune checkpoint therapies have revolutionized the clinical
management of malignant melanoma and now offer hope to patients with advanced …
management of malignant melanoma and now offer hope to patients with advanced …
Non-canonical functions of the ARF tumor suppressor in development and tumorigenesis
N Lagopati, K Belogiannis, A Angelopoulou… - Biomolecules, 2021 - mdpi.com
P14ARF (ARF; Alternative Reading Frame) is an extensively characterized tumor
suppressor which, in response to oncogenic stimuli, mediates cell cycle arrest and apoptosis …
suppressor which, in response to oncogenic stimuli, mediates cell cycle arrest and apoptosis …
[HTML][HTML] Mouse models of UV-induced melanoma: genetics, pathology, and clinical relevance
Melanocytes, a neural crest cell derivative, produce pigment to protect keratinocytes from
ultraviolet radiation (UVR). Although melanocytic lesions such as nevi and cutaneous …
ultraviolet radiation (UVR). Although melanocytic lesions such as nevi and cutaneous …