Abnormal cerebellar development in autism spectrum disorders

ME van der Heijden, JS Gill, RV Sillitoe - Developmental neuroscience, 2021 - karger.com
Autism spectrum disorders (ASD) comprise a group of heterogeneous neurodevelopmental
conditions characterized by impaired social interactions and repetitive behaviors with …

Understanding the role of oxidative stress, neuroinflammation and abnormal myelination in excessive aggression associated with depression: recent input from …

A Gorlova, E Svirin, D Pavlov, R Cespuglio… - International journal of …, 2023 - mdpi.com
Aggression and deficient cognitive control problems are widespread in psychiatric disorders,
including major depressive disorder (MDD). These abnormalities are known to contribute …

Cognitive-affective functions of the cerebellum

S Rudolph, A Badura, S Lutzu, SS Pathak… - Journal of …, 2023 - Soc Neuroscience
The cerebellum, traditionally associated with motor coordination and balance, also plays a
crucial role in various aspects of higher-order function and dysfunction. Emerging research …

Bidirectional control of fear memories by cerebellar neurons projecting to the ventrolateral periaqueductal grey

JL Frontera, H Baba Aissa, RW Sala… - Nature …, 2020 - nature.com
Fear conditioning is a form of associative learning that is known to involve different brain
areas, notably the amygdala, the prefrontal cortex and the periaqueductal grey (PAG). Here …

Climbing fibers provide essential instructive signals for associative learning

NT Silva, J Ramírez-Buriticá, DL Pritchett… - Nature …, 2024 - nature.com
Supervised learning depends on instructive signals that shape the output of neural circuits to
support learned changes in behavior. Climbing fiber (CF) inputs to the cerebellar cortex …

New horizons on non-invasive brain stimulation of the social and affective cerebellum

Z Cattaneo, C Ferrari, A Ciricugno, E Heleven… - The Cerebellum, 2022 - Springer
The cerebellum is increasingly attracting scientists interested in basic and clinical research
of neuromodulation. Here, we review available studies that used either transcranial …

Biosynthesis and signalling functions of central and peripheral nervous system neurosteroids in health and disease

E Lloyd-Evans, H Waller-Evans - Essays in Biochemistry, 2020 - portlandpress.com
Neurosteroids are steroid hormones synthesised de novo in the brain and peripheral
nervous tissues. In contrast to adrenal steroid hormones that act on intracellular nuclear …

[HTML][HTML] Functional topography of anger and aggression in the human cerebellum

J Klaus, DJLG Schutter - NeuroImage, 2021 - Elsevier
New insights into the functional neuro-anatomic correlates of emotions point toward the
involvement of the cerebellum in anger and aggression. To identify cerebellar regions …

Site-specific mitochondrial dysfunction in neurodegeneration

A Vodičková, SA Koren, AP Wojtovich - Mitochondrion, 2022 - Elsevier
Mitochondria are essential for neuronal survival and mitochondrial dysfunction is a hallmark
of neurodegeneration. The loss in mitochondrial energy production, oxidative stress, and …

Social memory deficit caused by dysregulation of the cerebellar vermis

OY Chao, SS Pathak, H Zhang, GJ Augustine… - Nature …, 2023 - nature.com
Social recognition memory (SRM) is a key determinant of social interactions. While the
cerebellum emerges as an important region for social behavior, how cerebellar activity …