The kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-
intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells …

Cystic fibrosis (CF) is widely known as a disease of the lung, even though it is in truth a
systemic disease, whose symptoms typically manifest in gastrointestinal dysfunction first. CF …

Spotted sea bass (Lateolabrax maculatus), possessing a superior adaptation ability to a
wide range of salinities, is a valuable candidate to develop saline-alkaline tolerant fish …

The urinary potassium (K+) excretion machinery is upregulated with increasing dietary K+,
but the role of accompanying dietary anions remains inadequately characterized. Poorly …

Background: In cystic fibrosis (CF), renal base excretion is impaired. Accordingly,
challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis …

Metabolic alkalosis is a widespread acid-base disturbance, especially in hospitalized
patients. It is characterized by the primary elevation of serum bicarbonate and arterial pH …

Secretin is a key hormone of the intestinal phase of digestion which activates pancreatic,
bile duct and Brunner gland HCO3− secretion. Recently, the secretin receptor (SCTR) was …

Objective: It is acknowledged that Radix Rehmanniae Praeparata (RR) can regulate
hormone metabolism, reduce blood glucose, resist aging, help to sedate patients and …

Renal tubules play an important role in maintaining water, electrolyte, and acid–base
balance. Renal tubule dysfunction can cause electrolyte disorders and acid–base …

Aim Renal excretion of excess HCO3− depends on renal cystic fibrosis transmembrane
conductance regulator (CFTR) and is impaired in people with cystic fibrosis (pwCF). Urine …