IBD, which primarily includes UC and Crohn's disease (CD), is a progressive, chronic and
relapsing condition. This debilitating disease is steadily becoming a worldwide medical …

Over 90% of cancer deaths are due to cancer cells metastasizing into other organs. Invasion
is a prerequisite for metastasis formation. Thus, inhibition of invasion can be an efficient way …

The murine neonatal heart can regenerate after injury through cardiomyocyte (CM)
proliferation, although this capacity markedly diminishes after the first week of life …

Summary Genomic amplification of 3q26. 2 locus leads to the increased expression of
microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC). Our results …

Background The determination of HER2 expression status contributes significantly to HER2-
targeted therapy in breast carcinoma. However, an economical, efficient, and non-invasive …

Peritoneal spread is the primary mechanism of metastasis of ovarian cancer, and survival of
ovarian cancer cells in the peritoneal cavity as nonadherent spheroids and their adherence …

Crosstalk and compensatory circuits within cancer signaling networks limit the activity of
most targeted therapies. For example, altered signaling in the networks activated by the …

Simple Summary Epithelial ovarian cancer (EOC) is the most fatal gynecological cancer with
poor survival rates and high mortality. EOC patients respond to standard platinum-based …

Abstract Lysyl oxidase-like 2 (LOXL2), a secreted enzyme that catalyzes the cross-linking of
collagen, plays an essential role in developmental angiogenesis. We found that …

ERBB2, a receptor tyrosine kinase amplified in breast cancer, is a well established regulator
of tumor growth in vivo and anoikis resistance leading to disruption of architecture in three …