Generalised anxiety disorder is a persistent and common disorder, in which the patient has
unfocused worry and anxiety that is not connected to recent stressful events, although it can …

The central issue raised in this paper is: can stress cause depression? Phrased more
precisely: can stress cause brain disturbances thought to underlie (certain forms of) …

A large number of 5-HT receptors (> 15) have been identified by molecular cloning
technology over the past 10 years. This review briefly summarizes available information …

Generalized anxiety disorder (GAD) is characterized by excessive worry about a variety of
topics. In addition to the presence of uncontrollable and persistent worry, the diagnosis of …

The inverse relation between serotonin and human aggression is often portrayed as
“reliable,”“strong,” and “well established” despite decades of conflicting reports and widely …

An overview of the behavioral data arising from the vast literature concerning the
involvement of 5-hydroxytryptamine (5-HT) neurotransmission in the regulation of anxiety is …

Pathologic aggression and anger are extremely heterogeneous phenomena present in a
variety of psychiatric and neurologic disorders, ranging from brain injury to schizophrenia …

Agitation is a nonspecific constellation of relatively unrelated behaviors that can be seen in a
number of different clinical conditions, usually presenting a fluctuating course. Multiple …

Anger has semantic, conceptual, and empirical links to psychopathology. It has long been
associated with madness, a diseased mind, and behavioral dyscontrol; claims of temporary …

Abstract Serotonin (5-hydroxytryptamine; 5-HT) has been implicated in a large number of
psychophysiologic processes including the regulation of sleep, appetite, mood, aggression …