Recent advances of PET imaging in clinical radiation oncology

M Unterrainer, C Eze, H Ilhan, S Marschner… - Radiation …, 2020 - Springer
Radiotherapy and radiation oncology play a key role in the clinical management of patients
suffering from oncological diseases. In clinical routine, anatomic imaging such as contrast …

[HTML][HTML] Systemic therapies for metastatic castration-resistant prostate cancer: an updated review

K Hatano, N Nonomura - The World Journal of Men's Health, 2023 - ncbi.nlm.nih.gov
The introduction of novel therapeutic agents for advanced prostate cancer has led to a wide
range of treatment options for patients with metastatic castration-resistant prostate cancer …

Diagnostic accuracy of 68Ga-PSMA-11 PET for pelvic nodal metastasis detection prior to radical prostatectomy and pelvic lymph node dissection: a multicenter …

TA Hope, M Eiber, WR Armstrong, R Juarez… - JAMA …, 2021 - jamanetwork.com
Importance The presence of pelvic nodal metastases at radical prostatectomy is associated
with biochemical recurrence after prostatectomy. Objective To assess the accuracy of …

PSMA and FDG-PET as predictive and prognostic biomarkers in patients given [177Lu] Lu-PSMA-617 versus cabazitaxel for metastatic castration-resistant prostate …

JP Buteau, AJ Martin, L Emmett, A Iravani… - The Lancet …, 2022 - thelancet.com
Background Previously, results from the TheraP trial showed that treatment with lutetium-177
[177 Lu] Lu-PSMA-617 improved frequency of prostate-specific antigen (PSA) response rate …

Health-related quality of life and pain outcomes with [177Lu] Lu-PSMA-617 plus standard of care versus standard of care in patients with metastatic castration-resistant …

K Fizazi, K Herrmann, BJ Krause, K Rahbar… - The Lancet …, 2023 - thelancet.com
Background In VISION, the prostate-specific membrane antigen (PSMA)-targeted
radioligand therapy lutetium-177 [177 Lu] Lu-PSMA-617 (vipivotide tetraxetan) improved …

Actinium-225-PSMA radioligand therapy of metastatic castration-resistant prostate cancer (WARMTH Act): a multicentre, retrospective study

MM Sathekge, IO Lawal, C Bal, F Bruchertseifer… - The Lancet …, 2024 - thelancet.com
Summary Background Actinium-225 (225 Ac) prostate-specific membrane antigen (PSMA)
radioligand therapy (RLT) is a novel therapy for metastatic castration-resistant prostate …

177Lu-PSMA-617 versus a change of androgen receptor pathway inhibitor therapy for taxane-naive patients with progressive metastatic castration-resistant prostate …

MJ Morris, D Castellano, K Herrmann, JS de Bono… - The Lancet, 2024 - thelancet.com
Summary Background [177 Lu] Lu-PSMA-617 (177 Lu-PSMA-617) prolongs radiographic
progression-free survival and overall survival in patients with metastatic castration-resistant …

Predictors and real-world use of prostate-specific radioligand therapy: PSMA and beyond

A Gafita, C Marcus, L Kostos, DM Schuster… - American Society of …, 2022 - ascopubs.org
PSMA is a transmembrane protein that is markedly overexpressed in prostate cancer,
making it an excellent target for imaging and treating patients with prostate cancer. Several …

89Zr-labeled PSMA ligands for pharmacokinetic PET imaging and dosimetry of PSMA-617 and PSMA-I&T: a preclinical evaluation and first in man

BM Privé, YHW Derks, F Rosar, GM Franssen… - European journal of …, 2022 - Springer
Rationale Prolonged in vivo evaluation of PSMA tracers could improve tumor imaging and
patient selection for 177 Lu-PSMA-617 and 177 Lu-PSMA-I&T. In this study, we present the …

Impact of DNA damage repair defects on response to PSMA radioligand therapy in metastatic castration-resistant prostate cancer

BM Privé, PHJ Slootbeek, BI Laarhuis… - Prostate cancer and …, 2022 - nature.com
Purpose Prostate-specific membrane antigen radioligand therapy (PSMA-RLT) is a novel
treatment for castration-resistant prostate cancer (mCRPC). While the majority of patients …