Tumor-associated macrophages are an abundant cell type in the tumor microenvironment.
These macrophages serve as a promising target for treatment of cancer due to their roles in …

The human body generates 10–100 billion cells every day, and the same number of cells
die to maintain homeostasis in our body. Cells infected by bacteria or viruses also die. The …

The TAM receptors—Tyro3, Axl, and Mer—comprise a unique family of receptor tyrosine
kinases, in that as a group they play no essential role in embryonic development. Instead …

The TAM receptor tyrosine kinases (RTKs)—T YRO3, A XL, and M ERTK—together with their
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …

Abstract TAM receptors (Tyro3, Axl, and Mer) belong to a family of receptor tyrosine kinases
that have important effects on hemostasis and inflammation. Also, they affect cell …

Exposure of phosphatidylserine on the outer leaflet of the plasma membrane is a surface
change common to many apoptotic cells. Normally restricted to the inner leaflet …

We report the identification of Iigands for Tyro 3 (alternatively called Sky, rse, brt, or tit) and
Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like …

Receptor tyrosine kinases have been shown to dysregulate a number of pathways
associated with tumor development, progression, and metastasis. Axl is a receptor tyrosine …

Vitamin K epoxide reductase (VKOR) is the target of warfarin, the most widely prescribed
anticoagulant for thromboembolic disorders. Although estimated to prevent twenty strokes …

Axl, Sky, and Mer, members of an Axl/Sky receptor tyrosine kinase subfamily, are typified by
the cell adhesion molecule-related extracellular domain. The product of growth arrest …