Neuropsychiatric disorders in Parkinson's disease: what do we know about the role of dopaminergic and non-dopaminergic systems?

K Dujardin, V Sgambato - Frontiers in neuroscience, 2020 - frontiersin.org
Besides the hallmark motor symptoms (rest tremor, hypokinesia, rigidity, and postural
instability), patients with Parkinson's disease (PD) have non-motor symptoms, namely …

Activation of 5-HT6 Receptors in the Ventrolateral Orbital Cortex Produces Anti-Anxiodepressive Effects in a Rat Model of Neuropathic Pain

YL Zhao, HY Yi, SS Baba, YX Guo, XC Yuan… - Molecular …, 2025 - Springer
The comorbidity of anxiety and depression frequently occurs in patients with neuropathic
pain. The ventrolateral orbital cortex (VLO) plays a critical role in mediating neuropathic pain …

Activation and blockade of α2-adrenoceptors in the prelimbic cortex regulate anxiety-like behaviors in hemiparkinsonian rats

Z Wu, T Wang, L Li, Y Hui, Q Zhang, H Yuan - Biochemical and Biophysical …, 2019 - Elsevier
At present, whether α 2-adrenoceptors in the prelimbic cortex (PrL) are involved in
Parkinson's disease-related anxiety is unclear. We examined the effects of PrL α 2 …

Anti-Anxiety Effects of Prelimbic 5-HT4 Receptors in the Rat Model of Parkinson's Disease: Evidence from Behavioral and Electrophysiological Study

Y Zhang, N Bai, H Wang… - Journal of Clinical and …, 2022 - ojs.bbwpublisher.com
Objective: Clinical and laboratory studies have demonstrated that prelimbic (PrL) and
serotonin-4 (5-HT 4) receptors may have the key role in regulating anxiety. However, the …