The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …

Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …

Mutations in Ras family proteins are implicated in 33% of human cancers, but direct
pharmacological inhibition of Ras mutants remains challenging. As an alternative to direct …

Lysosomes are important sites for macromolecular degradation, defined by an acidic
lumenal pH of∼ 4.5. To better understand lysosomal pH, we designed a novel, genetically …

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is a major public health
concern, but the mechanisms underlying its viral particle formation are not well understood …

Globally with over 10 million deaths per year, cancer is the most transversal disease across
countries, cultures, and ethnicities, affecting both developed and developing regions …

Quinine is a promising building block for creating polymer carriers for intracellular nucleic
acid delivery. This is due to its ability to bind to genetic material through intercalation and …

Acidification of secretory and endocytic organelles is required for proper receptor recycling,
membrane traffic, protein degradation, and solute transport. Proton-pumping vacuolar H+ …

Impaired activities and abnormally enlarged structures of endolysosomes are frequently
observed in Alzheimer disease (AD) brains. However, little is known about whether and how …