The transporter-mediated cellular uptake and efflux of pharmaceutical drugs and biotechnology products: how and why phospholipid bilayer transport is negligible in …

DB Kell - Molecules, 2021 - mdpi.com
Over the years, my colleagues and I have come to realise that the likelihood of
pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid …

An interplay of multiple positive and negative factors governs methicillin resistance in Staphylococcus aureus

BL Bilyk, VV Panchal, M Tinajero-Trejo… - Microbiology and …, 2022 - Am Soc Microbiol
The development of resistance to β-lactam antibiotics has made Staphylococcus aureus a
clinical burden on a global scale. MRSA (methicillin-resistant S. aureus) is commonly known …

[HTML][HTML] Staphylococcus aureus adapts to the immunometabolite itaconic acid by inducing acid and oxidative stress responses including S-bacillithiolations and S …

V Van Loi, T Busche, B Kuropka, S Müller… - Free Radical Biology …, 2023 - Elsevier
Staphylococcus aureus is a major pathogen, which has to defend against reactive oxygen
and electrophilic species encountered during infections. Activated macrophages produce …

Essential Fitness Repertoire of Staphylococcus aureus during Co-infection with Acinetobacter baumannii In Vivo

G Li, W Shen, Y Gong, M Li, X Rao, Q Liu, Y Yu… - Msystems, 2022 - Am Soc Microbiol
Staphylococcus aureus represents a major human pathogen that is frequently involved in
polymicrobial infections. However, the prevalence and role of co-infectious microbes on the …

Significant changes in cytoplasmic amino acid composition occur in the transition between mid-exponential and stationary phases of growth of Staphylococcus aureus …

M Alreshidi, H Dunstan, M MacDonald, M Saeed… - Microorganisms, 2023 - mdpi.com
The bacterial pathogen Staphylococcus aureus causes a wide range of infections that result
in high morbidity and mortality rates worldwide. S. aureus is known for its capacity to survive …

Stringent Response-Mediated Control of GTP Homeostasis Is Required for Long-Term Viability of Staphylococcus aureus

L Carrilero, L Urwin, E Ward, NR Choudhury… - Microbiology …, 2023 - Am Soc Microbiol
Staphylococcus aureus is an opportunistic bacterial pathogen that often results in difficult-to-
treat infections. One mechanism used by S. aureus to enhance survival during infection is …

Changes in Amino Acid Metabolism of Staphylococcus aureus following Growth to the Stationary Phase under Adjusted Growth Conditions

M Alreshidi, H Dunstan, T Roberts, F Bardakci… - Microorganisms, 2022 - mdpi.com
The sharp increase in infections due to Staphylococcus aureus is associated with its ability
to adapt to changes in its habitat. This study aimed to investigate the differences in the …

mSphere of Influence: Targeting bacterial signaling and metabolism to overcome antimicrobial resistance

MS Zeden - Msphere, 2024 - Am Soc Microbiol
ABSTRACT Dr Merve Suzan Zeden works in the field of molecular bacteriology and
antibiotic resistance. In this mSphere of Influence article, she reflects on how three papers …

Impact of inflammation and infection on the expression of amino acid transporters in the placenta: A minireview

ER McColl, M Hurtarte, M Piquette-Miller - Drug Metabolism and Disposition, 2022 - ASPET
Amino acid transporters expressed in the placenta help to regulate the transfer of amino
acids from maternal to fetal circulation. Nutritional or hormonal factors are known to …

Recent developments in our understanding of the physiology and nitric oxide-resistance of Staphylococcus aureus

AC Stephens, AR Richardson - Advances in Microbial Physiology, 2022 - Elsevier
Staphylococcus aureus is an important human pathogen causing a wide range of disease
presentations. It harbors a vast array of virulence factors and drug-resistance determinants …