Exposure to cellular stress can trigger the p53 tumor suppressor, a sequence-specific
transcription factor, to induce cell growth arrest or apoptosis. The choice between these …

Apoptotic cell death is executed by the caspase-mediated cleavage of various vital proteins.
Elucidating the consequences of this endoproteolytic cleavage is crucial for our …

Eukaryotic chromosomes are packaged in nuclei by many orders of folding. Little is known
about how higher-order chromatin packaging might affect gene expression. SATB1 is a cell …

Cytogenetic evidence, in the form of deletions and balanced translocations, points to the
existence of a locus on 2q32–q33, for which haploinsufficiency results in isolated cleft palate …

By altering chromatin structure, histone acetyltransferases (HATs) act as transcriptional
regulators. We observed in a model of primary neurons that histone acetylation levels …

Nuclear matrix attachment regions (MARs) are regulatory DNA sequences that are important
for higher-order chromatin organization, long-range enhancer function, and extension of …

Caspases are a family of aspartate-specific cysteine proteases responsible for the
biochemical and morphological changes that occur during the execution phase of apoptosis …

To study the role of caspase-6 during nuclear disassembly, we generated a chicken DT40
cell line in which both alleles of the caspase-6 gene were disrupted. No obvious …

The function of the subnuclear structure the promyelocytic leukaemia (PML) body is unclear
largely because of the functional heterogeneity of its constituents. Here, we provide the …

In vertebrates, the conserved Wnt signalling cascade promotes the stabilization and nuclear
accumulation of β-catenin, which then associates with the lymphoid enhancer factor/T cell …