Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …

There has been huge progress in the discovery of targeted cancer therapies in recent years.
However, even for the most successful and impactful cancer drugs which have been …

Protein phosphorylation is a major regulator of protein function and biological outcomes.
This was first recognized through functional biochemical experiments, and in the past …

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …

Alzheimer's Disease (AD) therapeutics based on the amyloid hypothesis have repeatedly
failed in clinical trials. Together with numerous reports that amyloid is present in brains from …

Kinases have been the focus of drug discovery programs for three decades leading to over
70 therapeutic kinase inhibitors and biophysical affinity measurements for over 130,000 …

The increasing population will challenge healthcare, particularly because the worldwide
population has never been older. Therapeutic solutions to age-related disease will be …

The advantage of natural compounds is their lower number of side-effects when compared
to most synthetic substances. Therefore, over the past several decades, the interest in …

Protein phosphorylation by eukaryotic protein kinases (ePKs) is a fundamental mechanism
of cell signaling in all organisms. In model vertebrates,~ 10% of ePKs are classified as …