Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first
examples were reported 18 years ago by Akiyama and Terada. Although they were …

The β-aminoketone moiety has been found to be the basic skeleton of several drugs such as
the amine salts “tolperisone (vasodilation)” and “oxyfedrine (therapeutic coronary disease)” …

A novel organocatalytic asymmetric formal [3+ 2] cycloaddition of 3-substituted 1H-indoles
with in situ generated 3-hydroxy-isoindolinone-derived β, γ-alkynyl-α-ketimines has been …

We disclose herein an enantioselective protocol for the Brønsted acid catalyzed addition of
naphthols to in situ generated naphthol-derived ortho-quinone methides (o-QMs) followed …

An enantioselective Friedel–Crafts reaction of cyclic α-diaryl N-acyl imines with indolizines
catalyzed by a chiral spirocyclic phosphoric acid has been developed. The asymmetric …

We report a highly regioselective 1, 2-addition of P (O)–H compounds to the in situ
generated β, γ-alkynyl-α-ketimine derived from 3-alkynyl-3-hydroxyisoindolinones, which …

Abstract A cascade C− H activation, annulation, and etherification of N‐hydroxybenzamides
with propargylamines provides a flexible route to N‐alkoxylated 3‐arylisoindolin‐1‐ones …

An enantioselective reaction of cyclic C-alkynyl imine precursor with thiols catalyzed by (R)-
H 8-TRIP has been described. A broad range of alkynyl isoindolinones possessing a single …

A brand-new procedure for the synthesis of 3-alkynylated 3, 3-disubstituted isoindolinones
has been disclosed via a HOTf or Fe (OTf) 3-catalyzed dehydrative alkynylation of 3 …

Herein, we report the first chiral phosphoric acid (CPA)-catalyzed asymmetric addition of α-
fluoro (phenylsulfonyl) methane (FSM) derivatives to in situ generated cyclic N-acyliminium …