Hereditary nonpolyposis colorectal cancer (HNPCC) dates to Warthin's description of family
G, which he began studying in 1895. Warthin's observations were not fully appreciated until …

The retinoblastoma gene, Rb, was originally identified as the tumor suppressor gene
mutated in a rare childhood cancer called retinoblastoma (reviewed in [1]). Subsequent …

The E2F1 transcription factor can promote proliferation or apoptosis when activated, and is a
key downstream target of the retinoblastoma tumour suppressor protein (pRB). Here we …

AIMS: Chromosomal gains and losses were surveyed by comparative genomic hybridisation
(CGH) in a series of colorectal adenomas and carcinomas, in search of high risk genomic …

Expression of cell cycle regulatory proteins was evaluated in premalignant and malignant
oral epithelial lesions, to test the hypothesis that protein regulation of the cell cycle may be …

The DiFi human colorectal cancer cell line was recently established from a familial
adenomatous polyposis patient with extracolonic features characteristic of the Gardner …

Levels of expression of the murine nm23 gene inversely correlate with metastatic potential in
several rodent tumor model systems. Expression of the human nm23 homologue also is …

Objective: MicroRNA-372 (miR-372) is reportedly shown to be an oncogene in human
testicular germ cell tumors and gastric cancers, but its expression in colorectal cancer (CRC) …

Scope It has been proposed that endogenously form N‐nitroso compounds (NOCs) are
partly responsible for the link between red meat consumption and colorectal cancer (CRC) …

The RHO family of small GTPases has multiple functions, including regulation of cytoskeletal
organization, cell cycle progression and cell migration, among others. The key members of …