DPP4 and ACE2 in diabetes and COVID-19: therapeutic targets for cardiovascular complications?
I Valencia, C Peiro, O Lorenzo… - Frontiers in …, 2020 - frontiersin.org
COVID-19 outbreak, caused by severe acute respiratory syndrome (SARS)-CoV-2
coronavirus has become an urgent health and economic challenge. Diabetes is a risk factor …
coronavirus has become an urgent health and economic challenge. Diabetes is a risk factor …
The roles of dipeptidyl peptidase 4 (DPP4) and DPP4 inhibitors in different lung diseases: new evidence
T Zhang, X Tong, S Zhang, D Wang, L Wang… - Frontiers in …, 2021 - frontiersin.org
CD26/Dipeptidyl peptidase 4 (DPP4) is a type II transmembrane glycoprotein that is widely
expressed in various organs and cells. It can also exist in body fluids in a soluble form …
expressed in various organs and cells. It can also exist in body fluids in a soluble form …
Sitagliptin activates the p62–Keap1–Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung …
L Kong, J Deng, X Zhou, B Cai, B Zhang, X Chen… - Cell death & …, 2021 - nature.com
Acute lung injury (ALI) is a complication of severe acute pancreatitis (SAP). Sitagliptin (SIT)
is a DPP4 inhibitor that exerts anti-inflammatory and antioxidant effects; however, its …
is a DPP4 inhibitor that exerts anti-inflammatory and antioxidant effects; however, its …
DPP4 inhibition by sitagliptin attenuates LPS-induced lung injury in mice
T Kawasaki, W Chen, YM Htwe… - American Journal of …, 2018 - journals.physiology.org
Acute respiratory distress syndrome (ARDS) is a severe clinical condition marked by acute
respiratory failure and dysregulated inflammation. Pulmonary vascular endothelial cells …
respiratory failure and dysregulated inflammation. Pulmonary vascular endothelial cells …
Systematic understanding of pathophysiological mechanisms of oxidative stress-related conditions—diabetes mellitus, cardiovascular diseases, and ischemia …
M Wang, Y Liu, Y Liang, K Naruse… - Frontiers in …, 2021 - frontiersin.org
Reactive oxygen species (ROS) plays a role in intracellular signal transduction under
physiological conditions while also playing an essential role in diseases such as …
physiological conditions while also playing an essential role in diseases such as …
Lidocaine attenuates hypoxia/reoxygenation‑induced inflammation, apoptosis and ferroptosis in lung epithelial cells by regulating the p38 MAPK pathway
X Ma, W Yan, N He - Molecular Medicine Reports, 2022 - spandidos-publications.com
Lung ischemia‑reperfusion (I/R) injury poses a serious threat to human health, worldwide.
The current study aimed to determine the role of lidocaine in A549 cells, in addition to the …
The current study aimed to determine the role of lidocaine in A549 cells, in addition to the …
Molecular Evidence of Adenosine Deaminase Linking Adenosine A2A Receptor and CD26 Proteins
E Moreno, J Canet, E Gracia, C Lluís, J Mallol… - Frontiers in …, 2018 - frontiersin.org
Adenosine is an endogenous purine nucleoside that acts in all living systems as a
homeostatic network regulator through many pathways, which are adenosine receptor (AR) …
homeostatic network regulator through many pathways, which are adenosine receptor (AR) …
Linagliptin protects against endotoxin-induced acute kidney injury in rats by decreasing inflammatory cytokines and reactive oxygen species
Septic shock can increase pro-inflammatory cytokines, reactive oxygen species (ROS), and
multiple organ dysfunction syndrome (MODs) and even lead to death. Dipeptidyl peptidase …
multiple organ dysfunction syndrome (MODs) and even lead to death. Dipeptidyl peptidase …
Repurposing existing drugs for COVID-19: an endocrinology perspective
FA Cadegiani - BMC endocrine disorders, 2020 - Springer
Abstract Background Coronavirus Disease 2019 (COVID-19) is a multi-systemic infection
caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), that …
caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), that …
Therapeutic targets for regulating oxidative damage induced by ischemia‐reperfusion injury: A study from a pharmacological perspective
WÁ Trujillo-Rangel, L García-Valdés… - Oxidative medicine …, 2022 - Wiley Online Library
Ischemia‐reperfusion (I‐R) injury is damage caused by restoring blood flow into ischemic
tissues or organs. This complex and characteristic lesion accelerates cell death induced by …
tissues or organs. This complex and characteristic lesion accelerates cell death induced by …