Macroautophagy (autophagy) delivers intracellular constituents to the lysosome to promote
catabolism. During development in multiple organisms, autophagy mediates various cellular …

First described by Randolph in 1897, the nature and main features of planarian neoblasts
have a long rambling history. While their morphologically undifferentiated features have long …

INTRODUCTION Understanding the differentiation of stem cells into the vast amount of cell
types that form the human body is a central problem of basic and medical science. The …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Many long-lived organisms, including humans, can regenerate some adult tissues lost to
physical injury or disease. Much of the previous research on mechanisms of regeneration …

Critical morphological requirements for pulp regeneration are tissues replete with
vascularisation, neuron formation, and dentin deposition. Autophagy was recently shown to …

Autophagy, a catabolic process responsible for the degradation of cytosolic components, is
upregulated when nutrient supplies are limited [1]. A critical step in autophagy induction …

A main goal of regenerative medicine is to replace lost or damaged tissues and organs with
functional parts of the correct size and shape. But the proliferation of new cells is not …

Planarians are capable of profound regenerative feats dependent upon a population of self-
renewing adult stem cells called neoblasts. The key features of neoblasts are their capacity …

Mechanisms determining final organ size are poorly understood. Animals undergoing
regeneration or ongoing adult growth are likely to require sustained and robust mechanisms …