[HTML][HTML] Obesity and obesity-induced inflammatory disease contribute to atherosclerosis: a review of the pathophysiology and treatment of obesity

RJ Henning - American journal of cardiovascular disease, 2021 - ncbi.nlm.nih.gov
Two billion people worldwide older than 18 years of age, or approximately 30% of the world
population, are overweight or obese. In addition, more than 43 million children under the …

Endothelial dysfunction and vascular disease–a 30th anniversary update

PM Vanhoutte, H Shimokawa, M Feletou… - Acta …, 2017 - Wiley Online Library
The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Endothelial dysfunction: is there a hyperglycemia-induced imbalance of NOX and NOS?

CA Meza, JD La Favor, DH Kim… - International journal of …, 2019 - mdpi.com
NADPH oxidases (NOX) are enzyme complexes that have received much attention as key
molecules in the development of vascular dysfunction. NOX have the primary function of …

Obesity and preeclampsia: common pathophysiological mechanisms

P Lopez-Jaramillo, J Barajas… - Frontiers in …, 2018 - frontiersin.org
Preeclampsia is a disorder specific of the human being that appears after 20 weeks of
pregnancy, characterized by new onset of hypertension and proteinuria. Abnormal …

Endothelial dysfunction in obesity

A Engin - Obesity and lipotoxicity, 2017 - Springer
Chronic inflammatory state in obesity causes dysregulation of the endocrine and paracrine
actions of adipocyte-derived factors, which disrupt vascular homeostasis and contribute to …

Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation

HS Abed, CS Samuel, DH Lau, DJ Kelly, SG Royce… - Heart rhythm, 2013 - Elsevier
BACKGROUND: Obesity is associated with atrial fibrillation (AF); however, the mechanisms
by which it induces AF are unknown. OBJECTIVE: To examine the effect of progressive …

[HTML][HTML] Regulation of obesity and insulin resistance by nitric oxide

BE Sansbury, BG Hill - Free radical biology and medicine, 2014 - Elsevier
Obesity is a risk factor for developing type 2 diabetes and cardiovascular disease and has
quickly become a worldwide pandemic with few tangible and safe treatment options …

Obesity and atherosclerosis: mechanistic insights

F Lovren, H Teoh, S Verma - Canadian Journal of Cardiology, 2015 - Elsevier
Obesity is a multifactorial chronic disease characterized by an accumulation of visceral and
subcutaneous fat, which leads to a predisposition toward cardiometabolic diseases. A …

Electrophysiological, electroanatomical, and structural remodeling of the atria as consequences of sustained obesity

R Mahajan, DH Lau, AG Brooks, NJ Shipp… - Journal of the American …, 2015 - jacc.org
Background: Obesity and atrial fibrillation (AF) are public health issues with significant
consequences. Objectives: This study sought to delineate the development of global …

Endothelial dysfunction in obesity and therapeutic targets

A Engin - Obesity and Lipotoxicity, 2024 - Springer
Parallel to the increasing prevalence of obesity in the world, the mortality from
cardiovascular disease has also increased. Low-grade chronic inflammation in obesity …