Overview of mass spectrometry-based metabolomics: opportunities and challenges

GAN Gowda, D Djukovic - Mass Spectrometry in Metabolomics: Methods …, 2014 - Springer
The field of metabolomics has witnessed an exponential growth in the last decade driven by
important applications spanning a wide range of areas in the basic and life sciences and …

Standardizing the experimental conditions for using urine in NMR-based metabolomic studies with a particular focus on diagnostic studies: a review

AH Emwas, C Luchinat, P Turano, L Tenori, R Roy… - Metabolomics, 2015 - Springer
The metabolic composition of human biofluids can provide important diagnostic and
prognostic information. Among the biofluids most commonly analyzed in metabolomic …

The strengths and weaknesses of NMR spectroscopy and mass spectrometry with particular focus on metabolomics research

AHM Emwas - Metabonomics: Methods and protocols, 2015 - Springer
Mass spectrometry (MS) and nuclear magnetic resonance (NMR) have evolved as the most
common techniques in metabolomics studies, and each brings its own advantages and …

Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice

V Lambert, J Lecomte, S Hansen, S Blacher… - Nature protocols, 2013 - nature.com
The mouse model of laser-induced choroidal neovascularization (CNV) has been used
extensively in studies of the exudative form of age-related macular degeneration (AMD) …

Metabolomic analysis of prostate cancer risk in a prospective cohort: The alpha‐tocopherol, beta‐carotene cancer prevention (ATBC) study

AM Mondul, SC Moore, SJ Weinstein… - … journal of cancer, 2015 - Wiley Online Library
Despite decades of concerted epidemiological research, relatively little is known about the
etiology of prostate cancer. As genome‐wide association studies have identified numerous …

Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide

MH Kulke, T O'Dorisio, A Phan… - Endocrine-Related …, 2014 - erc.bioscientifica.com
In this study, we i) assessed the metabolic profile of the normal adrenal cortex and medulla
of adult human subjects by means of 1 H-high-resolution magic-angle spinning nuclear …

Proteome–metabolome profiling of ovarian cancer ascites reveals novel components involved in intercellular communication

VO Shender, MS Pavlyukov, RH Ziganshin… - Molecular & Cellular …, 2014 - ASBMB
Ovarian cancer ascites is a native medium for cancer cells that allows investigation of their
secretome in a natural environment. This medium is of interest as a promising source of …

[HTML][HTML] Applications of metabolomics in cancer research

KA Vermeersch, MP Styczynski - Journal of carcinogenesis, 2013 - ncbi.nlm.nih.gov
The first discovery of metabolic changes in cancer occurred almost a century ago. While the
genetic underpinnings of cancer have dominated its study since then, altered metabolism …

Metabolomic studies of live single cancer stem cells using mass spectrometry

M Sun, Z Yang - Analytical chemistry, 2018 - ACS Publications
Cancer stem cells (CSCs) are rare types of cells responsible for tumor development,
relapse, and metastasis. However, current research in CSC biology is largely limited by the …

Biomarker discovery and translation in metabolomics

GA Nagana Gowda, D Raftery - Current Metabolomics, 2013 - ingentaconnect.com
The multifaceted field of metabolomics has witnessed exponential growth in both methods
development and applications. Owing to the urgent need, a significant fraction of research …