Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

3′ RNA decay pathways are critical for quality control and regulation of gene expression.
Structural and biochemical studies have provided insights into the key nucleases that carry …

Background Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer.
Although most patients are initially sensitive to first-line combination chemotherapy with …

Summary N 6-methyladenosine (m 6 A) is the most prevalent internal modification in
eukaryotic mRNAs and affects RNA processing and metabolism. When YTHDF2, an m 6 A …

Many biomolecular condensates appear to form through liquid–liquid phase separation
(LLPS). Individual condensate components can often undergo LLPS in vitro, capturing some …

Nonsense-mediated mRNA decay (NMD), which is arguably the best-characterized
translation-dependent regulatory pathway in mammals, selectively degrades mRNAs as a …

The 5′-terminal cap is a fundamental determinant of eukaryotic gene expression which
facilitates cap-dependent translation and protects mRNAs from exonucleolytic degradation …

To infect plants, pathogenic fungi secrete small proteins called effectors. Here, we describe
the catalytic activity and potential virulence function of the Nudix hydrolase effector AvrM14 …

Non-coding RNAs (ncRNAs) involve in diverse biological processes by post-transcriptional
regulation of gene expression. Emerging evidence shows that miRNA-4293 plays a …

Recent years have led to the identification of a number of enzymes responsible for RNA
decapping. This has provided a basis for further research to identify their role, dependency …