The innate immune system is the first line of host defense against infection and is comprised
of humoral and cellular mechanisms that recognize potential pathogens within minutes or …

Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble
protein vaccines, but the immune mechanisms underpinning this effect remain poorly …

Mannose binding lectin (MBL) is a protein of innate immunity that activates the complement
and promotes opsonophagocytosis. The deficiency of MBL due to several common gene …

We analyzed MBL2 gene variants in two cohorts of centenarians, octo‐nonagenarians and
nonagenarians, and in the general population, one from Sardinia Island (Italy), recruited in …

The role of mannose-binding lectin (MBL) deficiency (MBL2; XA/O and O/O genotypes) in
host defences remains controversial. The surfactant proteins (SP)-A1,-A2 and-D, other …

Background The gene MASP2 (mannan-binding lectin (MBL)-associated serine protease 2)
encodes two proteins, MASP-2 and MAp19 (MBL-associated protein of 19 kDa), bound in …

Purpose Mycobacterium leprae exploits complement activation and opsonophagocytosis to
infect phagocytes. M-ficolin is encoded by the FCN1 gene and initiates the lectin pathway on …

Chagas disease (CD) is caused by Trypanosoma cruzi, whose sugar moieties are
recognized by mannan binding lectin (MBL), a soluble pattern-recognition molecule that …

Due to its importance both in the clearance of pathogens that contribute as rheumatic
etiological agents and in the disposal of apoptotic bodies and potential autoimmune …

Either immune selection or stochastic processes may have influenced the frequency of
highly polymorphic genes such as mannose-binding lectin 2 (MBL2). This pattern …