Structural and functional modularity of the U2 snRNP in pre-mRNA splicing
C van der Feltz, AA Hoskins - Critical reviews in biochemistry and …, 2019 - Taylor & Francis
The U2 small nuclear ribonucleoprotein (snRNP) is an essential component of the
spliceosome, the cellular machine responsible for removing introns from precursor mRNAs …
spliceosome, the cellular machine responsible for removing introns from precursor mRNAs …
Structure of a pre-catalytic spliceosome
C Plaschka, PC Lin, K Nagai - Nature, 2017 - nature.com
Intron removal requires assembly of the spliceosome on precursor mRNA (pre-mRNA) and
extensive remodelling to form the spliceosome's catalytic centre. Here we report the cryo …
extensive remodelling to form the spliceosome's catalytic centre. Here we report the cryo …
Structure and conformational dynamics of the human spliceosomal Bact complex
D Haselbach, I Komarov, DE Agafonov, K Hartmuth… - Cell, 2018 - cell.com
The spliceosome is a highly dynamic macromolecular complex that precisely excises introns
from pre-mRNA. Here we report the cryo-EM 3D structure of the human B act spliceosome at …
from pre-mRNA. Here we report the cryo-EM 3D structure of the human B act spliceosome at …
Structure of the human activated spliceosome in three conformational states
During each cycle of pre-mRNA splicing, the pre-catalytic spliceosome (B complex) is
converted into the activated spliceosome (B act complex), which has a well-formed active …
converted into the activated spliceosome (B act complex), which has a well-formed active …
A challenging pie to splice: drugging the spliceosome
Since its discovery in 1977, the study of alternative RNA splicing has revealed a plethora of
mechanisms that had never before been documented in nature. Understanding these …
mechanisms that had never before been documented in nature. Understanding these …
JANUS, a spliceosome-associated protein, promotes miRNA biogenesis in Arabidopsis
MicroRNAs (miRNAs) are important regulators of genes expression. Their levels are
precisely controlled through modulating the activity of the microprocesser complex (MC) …
precisely controlled through modulating the activity of the microprocesser complex (MC) …
Arabidopsis JANUS regulates embryonic pattern formation through Pol II-mediated transcription of WOX2 and PIN7
F Xiong, HH Liu, CY Duan, BK Zhang, G Wei, Y Zhang… - Iscience, 2019 - cell.com
Embryonic pattern formation relies on positional coordination of cell division and
specification. Early axis formation during Arabidopsis embryogenesis requires WUSCHEL …
specification. Early axis formation during Arabidopsis embryogenesis requires WUSCHEL …
SF3b4: a versatile player in eukaryotic cells
F Xiong, S Li - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Spliceosomes are large protein-RNA complexes regulating pre-mRNA processing in
eukaryotes. SF3b4 encodes a core subunit of the U2-type spliceosome, loss-or gain-of …
eukaryotes. SF3b4 encodes a core subunit of the U2-type spliceosome, loss-or gain-of …
The SF3b complex is an integral component of the spliceosome and targeted by natural product-based inhibitors
NA Larsen - Macromolecular Protein Complexes III: Structure and …, 2021 - Springer
In this chapter, the essential role of the SF3b multi-protein complex will be discussed in the
context of the overall spliceosome. SF3b is critical during spliceosome assembly for …
context of the overall spliceosome. SF3b is critical during spliceosome assembly for …
Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid-protein interaction sites by mass spectrometry
LM Welp, T Sachsenberg, A Wulf, A Chernev… - bioRxiv, 2024 - biorxiv.org
UV (ultra-violet) crosslinking with mass spectrometry (XL-MS) has been established for
identifying RNA-and DNA-binding proteins along with their domains and amino acids …
identifying RNA-and DNA-binding proteins along with their domains and amino acids …