Genome-scale metabolic network models: From first-generation to next-generation
Over the last two decades, thousands of genome-scale metabolic network models (GSMMs)
have been constructed. These GSMMs have been widely applied in various fields, ranging …
have been constructed. These GSMMs have been widely applied in various fields, ranging …
Network reduction methods for genome-scale metabolic models
D Singh, MJ Lercher - Cellular and Molecular Life Sciences, 2020 - Springer
Genome-scale metabolic models (GSMs) provide a comprehensive representation of
cellular metabolism. GSMs provide a mechanistic link between cellular genotypes and …
cellular metabolism. GSMs provide a mechanistic link between cellular genotypes and …
Comprehensive understanding of Saccharomyces cerevisiae phenotypes with whole‐cell model WM_S288C
Biological network construction for Saccharomyces cerevisiae is a widely used approach for
simulating phenotypes and designing cell factories. However, due to a complicated …
simulating phenotypes and designing cell factories. However, due to a complicated …
Genomic sequencing, genome-scale metabolic network reconstruction, and in silico flux analysis of the grape endophytic fungus Alternaria sp. MG1
Background Alternaria sp. MG1, an endophytic fungus isolated from grape, is a native
producer of resveratrol, which has important application potential. However, the metabolic …
producer of resveratrol, which has important application potential. However, the metabolic …
In silico cell factory design driven by comprehensive genome-scale metabolic models: development and challenges
J Lu, X Bi, Y Liu, X Lv, J Li, G Du, L Liu - Systems Microbiology and …, 2023 - Springer
Genome-scale metabolic models (GEMs) have been widely used to design cell factories in
silico. However, initial flux balance analysis only considers stoichiometry and reaction …
silico. However, initial flux balance analysis only considers stoichiometry and reaction …
Genome-scale biological models for industrial microbial systems
N Xu, C Ye, L Liu - Applied microbiology and biotechnology, 2018 - Springer
The primary aims and challenges associated with microbial fermentation include achieving
faster cell growth, higher productivity, and more robust production processes. Genome-scale …
faster cell growth, higher productivity, and more robust production processes. Genome-scale …
Constraint-based metabolic modelling of marine microbes and communities
Constraint-based metabolic modelling (CBMM) consists in the use of computational
methods and tools to perform genome-scale simulations and predict metabolic features at …
methods and tools to perform genome-scale simulations and predict metabolic features at …
Development and applications of genome-scale metabolic network models.
J Qian, C Ye - Advances in Applied Microbiology, 2024 - europepmc.org
The genome-scale metabolic network model is an effective tool for characterizing the gene-
protein-response relationship in the entire metabolic pathway of an organism. By combining …
protein-response relationship in the entire metabolic pathway of an organism. By combining …
Analysis and modeling tools of metabolic flux
C Zhang, M Gong, X Lv, Y Liu, L Liu, G Du - Current Developments in …, 2022 - Elsevier
Metabolic engineering of microorganisms mainly involves the design, construction, and
optimization of microbial metabolic pathways, which is aimed to increase the yield of target …
optimization of microbial metabolic pathways, which is aimed to increase the yield of target …
Metabolic model reconstruction and analysis of an artificial microbial ecosystem
Microbial communities are widespread in the environment, and to isolate and identify
species or to determine relations among microorganisms, some 'omics methods like …
species or to determine relations among microorganisms, some 'omics methods like …