The FLT3 receptor is overexpressed on the majority of acute myeloid leukemia (AML) blasts.
Mutations in FLT3 are the most common genetic alteration in AML, identified in …

The receptor tyrosine kinase fms-like tyrosine kinase 3 (FLT3), involved in regulating
survival, proliferation, and differentiation of hematopoietic stem/progenitor cells, is …

Cancer has become a major public health problem worldwide. Researches focus on the
new approaches for cancer treatments that involve the specific targets of the cancer disease …

Because atherosclerotic cardiovascular disease is a leading cause of death worldwide,
understanding inflammatory processes underpinning its pathology is critical. B cells have …

Fms-like tyrosine kinase 3 (FLT3) is an important member of the class III receptor tyrosine
kinase (RTK) family, which is involved in the proliferation of hematopoietic cells and …

FMS-like tyrosine kinase 3 (FLT3) is mutated in approximately 30% of acute myeloid
leukemia (AML) patients. The presence of FLT3-ITD (internal tandem duplication, 20–25%) …

Acute myeloid leukemia (AML) is the most common and aggressive form of acute leukemia,
with a 5-year survival rate of just 24%. Over a third of all AML patients harbor activating …

Acute myeloid leukemia (AML) is a myeloid malignancy carrying a heterogeneous molecular
panel of mutations participating in the blockade of differentiation and the increased …

Pyrimidine-fused derivatives that are the inextricable part of DNA and RNA play a key role in
the normal life cycle of cells. Pyrimidine-fused dinitrogenous penta-heterocycles, including …

FLT3-ITD mutant has been observed in about 30% of AML patients and extensively studied
as a drug discovery target. On the basis of our previous study that ibrutinib (9) exhibited …