Sulfate-reducing bacteria (SRB) have a unique ability to respire under anaerobic conditions
using sulfate as a terminal electron acceptor, reducing it to hydrogen sulfide. SRB thrives in …

The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in
extracellular matrix proteins, and in integrin receptors. A number of human diseases arise …

The firm adhesion and transplatelet migration of leukocytes on vascular thrombus are both
dependent on the interaction of the leukocyte integrin, Mac-1, and a heretofore unknown …

Many protozoans of the phylum Apicomplexa are invasive parasites that exhibit a substrate-
dependent gliding motility. Plasmodium (malaria) sporozoites, the stage of the parasite that …

We have determined the high resolution crystal structure of the A domain from the a chain of
integrin CR3. The domain adopts a classic α/β “Rossmann” fold and contains an unusual …

Leptospira species colonize a significant proportion of rodent populations worldwide and
produce life-threatening infections in accidental hosts, including humans. Complete genome …

DFNA9 is an autosomal dominant, nonsyndromic, progressive sensorineural hearing loss
with vestibular pathology. Here we report three missense mutations in human COCH …

▪ Abstract Hereditary isolated hearing loss is genetically highly heterogeneous. Over 100
genes are predicted to cause this disorder in humans. Sixty loci have been reported and 24 …

To gain insight into the function of type VI collagen, the col6a1 gene was inactivated by
targeted gene disruption in the mouse. The homozygous mutants lacked collagen VI in the …

Adhesion of breast cancer cells is supported by various integrins. Cell adhesion is critical for
maintenance of both three-dimensional and normal function of these tissues. Several …