Three-dimensional (3D) fish hepatocyte cultures are promising alternative models for
replicating in vivo data. Few studies have attempted to characterise the structure and …

Lipid metabolism involves complex pathways, which are regulated in a similar way across
vertebrates. Hormonal and hypolipidemic deregulations cause lipid imbalance from fish to …

Fish are exposed to increased water temperatures and aquatic pollutants, including
endocrine-disrupting compounds (EDCs). Although each stressor can disturb fish liver …

Estrogens, estrogenic mimics and anti-estrogenic compounds are known to target estrogen
receptors (ER) that can modulate other nuclear receptor signaling pathways, such as those …

Simple Summary The liver is a vital organ for xenobiotic biotransformation and a prime
target for drug toxicity. The search for alternative experimental liver models in fish and other …

Peroxisome proliferators cause species-specific effects, which seem to be primarily
transduced by peroxisome proliferator-activated receptor alpha (PPARα). Interestingly …

Disruption of androgenic signaling has been linked to possible cross-modulation with other
hormone-mediated pathways. Therefore, our objective was to explore effects caused by …

The crosstalk between peroxisome proliferator-activated receptor α (PPARα) and estrogenic
pathways are shared from fish to humans. Salmonid fish had an additional genome …