Histone modifying enzymes play critical roles in many key cellular processes and are
appealing proteins for targeting by small molecules in disease. However, while the functions …

Transcript elongation by RNA polymerase is a dynamic process, capable of responding to a
number of intrinsic and extrinsic signals. A number of elongation factors have been identified …

Promoter-proximal pausing by initiated RNA polymerase II (Pol II) and regulated release of
paused polymerase into productive elongation has emerged as a major mechanism of …

During eukaryotic transcription elongation, RNA polymerase II (RNAP2) is regulated by a
chorus of factors. Here, we identified a common binary interaction module consisting of TFIIS …

The multisubunit Mediator (MED) complex bridges DNA-bound transcriptional regulators to
the RNA polymerase II (PolII) initiation machinery. In yeast, the 25 MED subunits are …

Eukaryotic transcription is dependent on specific histone modifications. Their recognition by
chromatin readers triggers complex processes relying on the coordinated association of …

The transcription elongation factor TFIIS induces mRNA cleavage by enhancing the intrinsic
nuclease activity of RNA polymerase (Pol) II. We have diffused TFIIS into Pol II crystals and …

Transcribing RNA polymerases oscillate between three stable states, two of which, pre-and
posttranslocated, were previously subjected to x-ray crystal structure determination. We …

Human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75)
protein was recently identified as a binding partner for HIV-1 integrase (IN) in human cells. In …

The human cofactor complexes ARC (activator-recruited cofactor) and CRSP (cofactor
required for Sp1 activation) mediate activator-dependent transcription in vitro. Although …