Abstract The reaction of 3-amino-5-phenylaminopyrazoles 2 with 3-(dimethylamino)
acrylonitrile derivatives resulted in a series of substituted pyrazolopyrimidine analogues 4 …

Emerging and re-emerging viruses periodically cause outbreaks and epidemics all over the
world, eventually leading to global events such as the current pandemic of the novel SARS …

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial
therapies. Recent results from our laboratories from two structurally related scaffolds have …

Carbocyclic nucleoside analogues have a distinguished history as anti-infectious agents,
including key antiviral agents. Toxicity was initially a concern but this was reduced by the …

Here we report the synthesis and biological activity of new 5′-norcarbocyclic derivatives of
bicyclic pyrrolo-and furano [2, 3-d] pyrimidines with different substituents in the heterocyclic …

The pandemic caused by the novel betacoronavirus SARS-CoV-2 has already claimed more
than 3.5 million lives. Despite the development and use of anti-COVID-19 vaccines, the …

Традиционные средства адресной доставки наноструктур, такие, как антитела,
трансферрин, лектины или аптамеры, зачастую могут вызывать целый спектр …

Введение. Для нужд медицины синтезировано множество веществ с различными
механизмами действия, которые с успехом применяются для лечения болезней, ранее …

Novel types of the 5'-norcarbocyclic analogues of nucleosides have been designed, and
new biological targets and mechanisms of action of these compounds have been found. The …

Пандемия, вызванная новым бетакоронавирусом SARS-CoV-2, унесла уже почти 5 млн
жизней. Несмотря на разработку и широкое применение вакцин против COVID-19, это …