There is a growing body of scientific research showing the link between depression and
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

The hypothalamic–pituitary–adrenal (HPA) axis has been implicated in the pathophysiology
of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated …

Chronic stress and high levels of glucocorticoids produce functional and structural changes
in brain and especially in the hippocampus, an important limbic system structure that plays a …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Background Alzheimer's disease (AD) is the commonest cause of dementia, with
approximately 5 million new cases occurring annually. Despite decades of research, its …

Increased peripheral and central nervous system cortisol levels have been reported in
Alzheimer's disease (AD) and may reflect dysfunction of cerebral components of the …

Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in
neuronal differentiation, cell survival, and synaptic function in the peripheral and central …

Depression (MDD) is prodromal to, and a component of, Alzheimer's disease (AD): it may
also be a trigger for incipient AD. MDD is not a unitary disorder, so there may be particular …

Introduction The pathophysiology of delirium after cardiac surgery is largely unknown.
Thepurpose of this study was to investigate whether increased concentration ofpreoperative …