The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

G protein-coupled receptors (GPCRs) are the largest class of receptors in the human
genome and some of the most common drug targets. It is now well established that GPCRs …

Decreased dendritic spine density in the cortex is a hallmark of several neuropsychiatric
diseases, and the ability to promote cortical neuron growth has been hypothesized to …

Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …

INTRODUCTION Neuromodulators, such as dopamine, norepinephrine, or serotonin, exert
powerful control over neural circuit dynamics that give rise to diverse neural function and …

Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its
receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) …

G-protein-coupled receptors (GPCRs), the largest family of signalling receptors, as well as
important drug targets, are known to activate extracellular-signal-regulated kinase (ERK)—a …

Newly endocytosed integral cell surface proteins are typically either directed for degradation
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …

Genetically encoded dopamine sensors based on green fluorescent protein (GFP) enable
high-resolution imaging of dopamine dynamics in behaving animals. However, these GFP …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …