BCL6 was initially discovered as an oncogene in B-cell lymphomas, where it drives the
malignant phenotype by repressing proliferation and DNA damage checkpoints and …

Background Breast cancer is considered the number one killer of women both in China and
abroad, and the leading cause of cancer death. It severely affects female health-related …

Abstract B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor, is involved in the
development and progression of breast cancers with uncertain mechanism. The purpose of …

Ubiquitination is essential for regulation of cell physiology, protein stability, and signal
transduction [1]. Its dysregulation is an important factor in many diseases, including cancer …

Introduction and Objectives. MicroRNA (miRNA) expression is altered in urologic
malignancies, including urothelial carcinoma of the bladder (UCB). Individual miRNAs have …

MicroRNAs have emerged as important regulators of the metastatic process. In addition,
circulating miRNAs appear to be surprisingly stable in peripheral blood making them ideal …

Background: Dysregulation of BCL6 plays critical oncogenic roles and facilitates
tumorigenesis in various malignancies. However, whether the aberrant expression of BCL6 …

With over 60,000 cases diagnosed annually in the US, ductal carcinoma in situ (DCIS) is the
most prevalent form of early-stage breast cancer. Because many DCIS cases never progress …

Zinc-finger and BTB/POZ domain-containing family proteins (ZBTB) are important
transcription factors functioning as tumor suppressors or oncogenes, such as BCL6/ZBTB27 …

B-cell lymphoma 6 (BCL6), a proto-oncogene, is an evolutionarily conserved zinc finger
protein that functions as a transcriptional repressor. BCL6 is the master regulator of B …