Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous
concern in every transplantation proceeding, from whole organs to modest grafts. Given its …

Hyperlipidemia is a well-established risk factor for developing cardiovascular disease
(CVD). The recent American College of Cardiology and American Heart Association …

The mouse retina has been used extensively over the past decades to study both
physiologic and pathologic angiogenesis. Over time, various mouse retina models have …

Retinal ischemia is a common cause of visual impairment and blindness. At the cellular
level, ischemic retinal injury consists of a self-reinforcing destructive cascade involving …

The retinal pigment epithelium (RPE) is an specialized epithelium lying in the interface
between the neural retina and the choriocapillaris where it forms the outer blood‐retinal …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Of all the chemical elements, oxygen is the most vital to the human body. The brain is the
most sensitive organ to oxygen deprivation (hypoxia), which, over an extended period, can …

Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

Background Although vascular endothelial growth factor (VEGF) is a primary mediator of
retinal angiogenesis, VEGF inhibition alone is insufficient to prevent retinal …

Erythropoietin mediates an evolutionarily conserved, ancient immune response that limits
damage to the heart, the nervous system and other tissues following injury. New evidence …