The endocannabinoid system (ECS) regulates brain development and function, energy
metabolism and stress in a sex-, age-and tissue-dependent manner. The ECS comprises …

The legalization of cannabis in some states has intensified interest in the potential for
cannabis and its constituents to lead to novel therapeutics for pain. Our understanding of the …

The endocannabinoid system (ECS) critically regulates stress responsivity and emotional
behavior throughout development. It regulates anxiety‐like behaviors in humans and animal …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, characterized by social
interaction impairment, stereotypical/repetitive behaviors and emotional deregulation. The …

Needle procedures are among the most common causes of pain and distress for individuals
seeking health care. While needle pain is especially problematic for children needle pain …

Understanding sex differences in behavioral and molecular effects of stress has important
implications for understanding the vulnerability to chronic psychiatric disorders associated …

Objectives: This structured, prospective questionnaire-based cohort was aimed to assess
long-term effectiveness and safety of cannabis oil extracts in patients with chronic pain …

Necrotizing enterocolitis (NEC) is a relatively rare but very severe gastrointestinal disease
primarily affecting very preterm infants. NEC is characterized by excessive inflammation and …

Newborn mammals display robust responses to noxious or tissuedamaging stimulation.
These nociceptive or “pain” responses arise from neural activity at different levels of the …

Objectives: We examined whether neonatal complete Freund's adjuvant (CFA)-induced
inflammation induced or altered adult development of hyperalgesic priming (inflammation …