In addition to their roles in IGF transport, the six IGF-binding proteins (IGFBPs) regulate cell
activity in various ways. By sequestering IGFs away from the type I IGF receptor, they may …

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/phosphatidylinositol 3-
kinase (PI3K)/AKT constitute an important pathway regulating the signaling of multiple …

Mammary gland involution is characterized by extensive apoptosis of the epithelial cells. At
the onset of involution, Stat3 is specifically activated. To address the function of this …

ABSTRACT A persistent lactation is dependent on maintaining the number and activity of
milk secreting cells with advancing lactation. When dairy cows are milked twice daily, the …

The insulin-like growth factor binding proteins (IGFBPs) area family of six proteins that bind
to insulin-like growth factor-I and-II with very high affinity. Because their affinity constants are …

Diet contributes to over one-third of cancer deaths in the Western world, yet the factors in the
diet that influence cancer are not elucidated. A reduction in caloric intake dramatically slows …

The IGF system components have been implicated in breast cancer progression. IGF-I and
IGF-II are mitogenic and anti-apoptotic peptides that influence the proliferation of various cell …

Previous studies from this laboratory have emphasized the essential role of GH in pubertal
mammary development and shown that insulin-like growth factor I (IGF-I) was capable of …

This review aims to summarize experimental evidence supporting the role of the insulin‐like
growth factor (IGF) signalling system in the progression, maintenance, and treatment of …

Insulin-like growth factor (IGF) signaling is regulated by a conserved family of IGF binding
proteins (IGFBPs) in vertebrates. Among the six distinct types of IGFBPs, IGFBP-5 is the most …