[HTML][HTML] Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies

MA Sanchez-Garrido, M Tena-Sempere - Molecular metabolism, 2020 - Elsevier
Background Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among
reproductive age women. Although its cardinal manifestations include hyperandrogenism …

Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome

S Risal, Y Pei, H Lu, M Manti, R Fornes, HP Pui… - Nature Medicine, 2019 - nature.com
How obesity and elevated androgen levels in women with polycystic ovary syndrome
(PCOS) affect their offspring is unclear. In a Swedish nationwide register-based cohort and a …

Hyperandrogenemia and insulin resistance: The chief culprit of polycystic ovary syndrome

J Wang, D Wu, H Guo, M Li - Life sciences, 2019 - Elsevier
Polycystic ovary syndrome (PCOS) is one of the most common systemic reproductive
endocrine diseases, which has a variety of effects on a woman's health. Because of the …

[HTML][HTML] The global epidemic of the metabolic syndrome

MG Saklayen - Current hypertension reports, 2018 - Springer
Metabolic syndrome, variously known also as syndrome X, insulin resistance, etc., is defined
by WHO as a pathologic condition characterized by abdominal obesity, insulin resistance …

New perspectives on the pathogenesis of PCOS: neuroendocrine origins

KA Walters, RB Gilchrist, WL Ledger, HJ Teede… - Trends in Endocrinology …, 2018 - cell.com
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-
aged women. It is characterized by reproductive, endocrine, metabolic, and psychological …

Involvement of novel adipokines, chemerin, visfatin, resistin and apelin in reproductive functions in normal and pathological conditions in humans and animal models

A Estienne, A Bongrani, M Reverchon, C Ramé… - International journal of …, 2019 - mdpi.com
It is well known that adipokines are endocrine factors that are mainly secreted by white
adipose tissue. Their central role in energy metabolism is currently accepted. More recently …

The mechanism of androgen actions in PCOS etiology

V Rodriguez Paris, MJ Bertoldo - Medical sciences, 2019 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-
age women. By comprising reproductive, endocrine, metabolic and psychological features …

Adipose mesenchymal stem cell–derived exosomal microRNAs ameliorate polycystic ovary syndrome by protecting against metabolic disturbances

M Cao, Y Zhao, T Chen, Z Zhao, B Zhang, C Yuan… - Biomaterials, 2022 - Elsevier
Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in
women of childbearing age. Adipose mesenchymal stem cells (AMSCs) secrete cytokines …

Sex differences in brown adipose tissue function: sex hormones, glucocorticoids, and their crosstalk

K Kaikaew, A Grefhorst, JA Visser - Frontiers in endocrinology, 2021 - frontiersin.org
Excessive fat accumulation in the body causes overweight and obesity. To date, research
has confirmed that there are two types of adipose tissue with opposing functions: lipid …