A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes

JJ Taylor, PM Preshaw, E Lalla - Journal of clinical …, 2013 - Wiley Online Library
Aims To review the evidence for the molecular and cellular processes that may potentially
link periodontal disease and diabetes. The pathogenic roles of cytokines and metabolic …

Rational design of bioactive hydrogels toward periodontal delivery: from pathophysiology to therapeutic applications

Y Yin, S Yang, D Ai, H Qin, Y Sun, X Xia… - Advanced Functional …, 2023 - Wiley Online Library
Periodontitis is a biofilm‐induced, host‐mediated inflammatory disease that results in
periodontal tissue destruction. The design of functional biomaterials based on disease …

Periodontitis: oral complication of diabetes

PM Preshaw, SM Bissett - Endocrinology and Metabolism …, 2013 - endo.theclinics.com
Periodontitis is a common chronic inflammatory disease that affects the tissues that support
and invest the teeth. These tissues include the gingiva (or gum, the visible part of pink tissue …

Advanced glycation end‐products increase IL‐6 and ICAM‐1 expression via RAGE, MAPK and NF‐κB pathways in human gingival fibroblasts

K Nonaka, Y Kajiura, M Bando… - Journal of …, 2018 - Wiley Online Library
Background and Objectives Diabetes mellitus (DM) is a risk factor for periodontal diseases
and may exacerbate the progression of the pathogenesis of periodontitis. Advanced …

Local inflammatory reactions in patients with diabetes and periodontitis

SK Sonnenschein, J Meyle - Periodontology 2000, 2015 - Wiley Online Library
The impact of diabetes mellitus on the prevalence, severity and progression of periodontal
disease has been known for many years and intense efforts have been made to elucidate …

Salivary advanced glycated end products, their receptors, and aMMP‐8 in periodontitis patients with varying glycemic levels: A cross‐sectional study

JT Thomas, B Joseph, S Varghese… - Journal of …, 2024 - Wiley Online Library
Background Advanced glycation end products (AGE) and their receptors (RAGE) have been
implicated in developing periodontal complications in diabetic patients. This study aimed to …

The link between advanced glycation end products and apoptosis in delayed wound healing

A Shaikh‐Kader, NN Houreld… - Cell Biochemistry …, 2019 - Wiley Online Library
Advanced glycation end products (AGEs) are naturally occurring molecules that start to
accumulate from embryonic developmental stages and form as part of normal ageing. When …

Pathogenic molecular mechanisms in periodontitis and peri-implantitis: Role of advanced glycation end products

G Plemmenos, C Piperi - Life, 2022 - mdpi.com
Advanced Glycation End Products (AGEs), the products of the non-enzymatic oxidation of
proteins, nucleic acids, and lipids, are accumulated in periodontal tissues under …

Periodontal health in a cohort of subjects with type 1 diabetes mellitus

M Roy, G Gastaldi, DS Courvoisier… - Clinical and …, 2019 - Wiley Online Library
To evaluate periodontal health and oral health behaviors in a cohort of subjects with type 1
diabetes (T1D), 50 persons with T1D (30 males and 20 females; mean age: 35.2 years) …

Are inflamed periodontal tissues endogenous source of advanced glycation end-products (AGEs) in individuals with and without diabetes mellitus? A systematic …

A Chopra, TN Jayasinghe, J Eberhard - Biomolecules, 2022 - mdpi.com
Advanced glycation end-products (AGEs) are heterogeneous compounds formed when
excess sugars condense with the amino groups of nucleic acids and proteins. Increased …