Metalloantimalarials

PF Salas, C Herrmann, C Orvig - Chemical reviews, 2013 - ACS Publications
Malaria is a worldwide neglected infectious disease that, despite decades of research
invested in its prevention and treatment, remains one of the main causes of mortality and …

A structural chemistry perspective on the antimalarial properties of thiosemicarbazone metal complexes

KL Summers - Mini Reviews in Medicinal Chemistry, 2019 - ingentaconnect.com
Malaria is a potentially life-threatening disease, affecting approx. 214 million people
worldwide. Malaria is caused by a protozoan, Plasmodium falciparum, which is transmitted …

Theoretical analysis of the binding of iron (III) protoporphyrin IX to 4-methoxyacetophenone thiosemicarbazone via DFT-D3, MEP, QTAIM, NCI, ELF, and LOL studies

NK Nkungli, JN Ghogomu - Journal of Molecular Modeling, 2017 - Springer
Thiosemicarbazones display diverse pharmacological properties, including antimalarial
activities. Their pharmacological activities have been studied in depth, but little of this …

Synthesis, cytotoxicity and antimalarial activities of thiosemicarbazones and their nickel (II) complexes

S Savir, ZJ Wei, JWK Liew, I Vythilingam… - Journal of Molecular …, 2020 - Elsevier
A series of Schiff base metal complexes with the formulations [Ni (L1) 2](4),[Ni (L2) 2](5) and
[Ni (L3) 2](6),(where 1 or L1= fluorene-2-carboxaldehyde thiosemicarbazone, 2 or L2 …

Nickel (II) complexes with polyhydroxybenzaldehyde and O, N, S tridentate thiosemicarbazone ligands: Synthesis, cytotoxicity, antimalarial activity, and molecular …

S Savir, JWK Liew, I Vythilingam, YAL Lim… - Journal of Molecular …, 2021 - Elsevier
A series of Schiff base metal complexes with the formulations [Ni (L1) PPh 3] Cl (1),[Ni (L2)
PPh 3] Cl (2),[Ni (L3) PPh 3](3), and [Ni (L4) PPh 3](4)(where L1= 2, 3, 4 …

Tridentate xanthene-based hydrazone ligands and their mononuclear transition metal complexes: synthesis, anti-malarial, antimicrobial and molecular docking …

M Rani, J Devi, B Kumar, T Arora, B Taxak - Research on Chemical …, 2024 - Springer
In the search of potential multi-target medicinal agents, new NOO-tridentate hydrazone
ligands (H2L1–H2L4)(1–4) and their transition metal (II) complexes (5–20) were synthesized …

Synthesis and antimalarial activity of metal complexes of cross-bridged tetraazamacrocyclic ligands

TJ Hubin, PNA Amoyaw, KD Roewe… - Bioorganic & medicinal …, 2014 - Elsevier
Using transition metals such as manganese (II), iron (II), cobalt (II), nickel (II), copper (II), and
zinc (II), several new metal complexes of cross-bridged tetraazamacrocyclic chelators …

Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents

A Inam, SM Siddiqui, TS Macedo, DRM Moreira… - European Journal of …, 2014 - Elsevier
N-Acylhydrazones derived from 7-chloro-4-piperazin-1-yl-quinoline were synthesized and
biologically evaluated for blood-stage of Plasmodium falciparum and Entamoeba histolytica …

Synthesis and comparison of antileishmanial and cytotoxic activities of S-(−)-limonene benzaldehyde thiosemicarbazones with their R-(+)-analogues

SAA Batista, F Vandresen, H Falzirolli, E Britta… - Journal of Molecular …, 2019 - Elsevier
In this study, we explore a series of novel potential antiprotozoal S-(−)-limonene-based
benzaldehyde thiosemicarbazones were synthesised and their activity effective against the …

Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids

MF Ansari, SM Siddiqui, K Ahmad, F Avecilla… - European Journal of …, 2016 - Elsevier
In continuation of our previous work, a series of furan-thiazolidinone hybrids was prepared
by Knoevenagel condensation of 3-(furan-2-ylmethyl)-2-(phenylimino)-1, 3-thiazolidin-4-one …