Progress has been made in our understanding of the mechanisms of endoplasmic reticulum
(ER) proteostasis, ER stress and the unfolded protein response (UPR), as well as ER stress …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Cardiolipin (CL) is a unique, tetra-acylated diphosphatidylglycerol lipid that mainly localizes
in the inner mitochondria membrane (IMM) in mammalian cells and plays a central role in …

Calcium-independent phospholipase A 2 γ (iPLA 2 γ)/patatin-like phospholipase domain-
containing lipase 8 (PNPLA8) is one of the iPLA 2 enzymes, which do not require Ca 2+ ion …

Fluvastatin (FLV) is a statin family member that may play a role in modulating a variety of
medical disorders such as atherosclerosis and breast cancer. The present study addresses …

Podocyte injury and endoplasmic reticulum (ER) stress have been implicated in the
pathogenesis of various glomerular diseases. ERdj3 (DNAJB11) and mesencephalic …

Abstract αKlotho (Klotho) has well established renoprotective effects; however, the
molecular pathways mediating its glomerular protection remain incompletely understood …

Patatin-like phospholipase domain-containing protein PNPLA8, also termed Ca2+-
independent phospholipase A2γ (iPLA2γ), is addressed to the mitochondrial matrix (or …

Intracellular processes can be localized for efficiency or regulation. For example, localized
mRNA translation by chloroplastic ribosomes occurs in the biogenesis of PSII, one of the two …

Protein misfolding in the endoplasmic reticulum (ER) of podocytes contributes to the
pathogenesis of glomerular diseases. Protein misfolding activates the unfolded protein …