Translation is an emerging constraint on protein homeostasis in ageing

J Llewellyn, SJ Hubbard, J Swift - Trends in Cell Biology, 2024 - cell.com
Proteins are molecular machines that provide structure and perform vital transport, signalling
and enzymatic roles. Proteins expressed by cells require tight regulation of their …

Computational modeling establishes mechanotransduction as a potent modulator of the mammalian circadian clock

EA Francis, P Rangamani - Journal of Cell Science, 2024 - journals.biologists.com
Mechanotransduction, which is the integration of mechanical signals from the external
environment of a cell to changes in intracellular signaling, governs many cellular functions …

Clock gene Per2 modulates epidermal tissue repair in vivo

VQ Yujra, EJD Silveira, DA Ribeiro… - Journal of Cellular …, 2024 - Wiley Online Library
Wound healing can be influenced by genes that control the circadian cycle, including Per2
and BMAL1, which coordinate the functions of several organs, including the skin. The aim of …

Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community

MJ Dalby, V Pekovic‐Vaughan, DP Shanley… - …, 2024 - Wiley Online Library
Ageing causes progressive decline in metabolic, behavioural, and physiological functions,
leading to a reduced health span. The extracellular matrix (ECM) is the three‐dimensional …

[PDF][PDF] An American Journal of Physiology-Cell Physiology for the present and the future

A Nyström, L Schaefer - American Journal of Physiology …, 2023 - journals.physiology.org
First, our Impact Factor rose from 5.282 in 2021 to 5.5 in 2022. The Cite Score of the Journal
38 increased from 7.3 in 2021 to 8.3 in 2022. This is a great success, especially considering …

DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis

SJ Chen, F Yu, X Feng, Q Li, YH Jiang, LQ Zhao… - Cell Communication and …, 2024 - Springer
Background The alveolar epithelial type II cell (AT2) and its senescence play a pivotal role in
alveolar damage and pulmonary fibrosis. Cell circadian rhythm is strongly associated with …

[PDF][PDF] The intertwined aging, the extracellular matrix, and fibrosis

A Nyström - American Journal of Physiology-Cell …, 2024 - journals.physiology.org
The intertwined ageing, the extracellular matrix, and fibrosis Page 1 1 The intertwined ageing,
the extracellular matrix, and fibrosis 1 Alexander Nyström1 2 1Department of Dermatology …

Integrative Meta-Analysis: Unveiling Genetic Factors in Meat Sheep Growth and Muscular Development through QTL and Transcriptome Studies

SU Rehman, Y Zhen, L Ding, AA Saleh, Y Zhang… - Animals, 2024 - mdpi.com
Simple Summary This meta-analysis examines the impact of neutering on sheep production
and quality, focusing on performance, carcass characteristics, and meat quality. It is …

Relationship between circadian rhythm-related genes and extracellular matrix: implications for sleep deprivation

X Liu, J Sun, Z Ling, T Dong - Sleep and Breathing, 2024 - Springer
Background Sleep deprivation (SD) can lead to the development of various pathological
disorders. The extracellular matrix (ECM) compositions and circadian rhythm genes are two …

Age-Related Differences in the Mouse Corneal Epithelial Transcriptome and Their Impact on Corneal Wound Healing

A Abu-Romman, KK Scholand… - … & Visual Science, 2024 - iovs.arvojournals.org
Purpose: Aging is a risk factor for dry eye. We sought to identify changes in the aged mouse
corneal epithelial transcriptome and determine how age affects corneal sensitivity, re …