Oral and topical administration of a geranyl acetophenone attenuates DNCB-induced atopic dermatitis-like skin lesions in BALB/c mice
Atopic dermatitis (AD) is a chronic, allergic inflammatory skin disorder that lacks a definite
cure. Using a mouse DNCB-induced AD-like skin lesions model, this study evaluated the …
cure. Using a mouse DNCB-induced AD-like skin lesions model, this study evaluated the …
Virtual screening, ADME study, and molecular dynamic simulation of chalcone and flavone derivatives as 5-Lipoxygenase (5-LO) inhibitor
SN Mohd Amin, MH Md Idris, M Selvaraj… - Molecular …, 2020 - Taylor & Francis
Lipoxygenase (5-LO) is one of the key enzymes involved in the production of pro-
inflammatory mediators, such as leukotriene B4 and cysteinyl leukotrienes. Inhibition of 5-LO …
inflammatory mediators, such as leukotriene B4 and cysteinyl leukotrienes. Inhibition of 5-LO …
Britanin attenuates ovalbumin-induced airway inflammation in a murine asthma model
SG Kim, E Lee, NY Park, HH Park, KT Jeong… - Archives of pharmacal …, 2016 - Springer
We previously demonstrated the alleviation of ovalbumin (OVA)-induced airway
inflammation by Inulae flos. In the present study, the effects of britanin, a sesquiterpene …
inflammation by Inulae flos. In the present study, the effects of britanin, a sesquiterpene …
The protective effects of a synthetic geranyl acetophenone in a cellular model of TNF-α-induced pulmonary epithelial barrier dysfunction
Alveolar epithelial barrier dysfunction contributes to lung edema and can lead to acute lung
injury (ALI). The features include increased epithelial permeability, upregulation of …
injury (ALI). The features include increased epithelial permeability, upregulation of …
Anti-allergic activity of 2, 4, 6-trihydroxy-3-geranylacetophenone (tHGA) via attenuation of IgE-mediated mast cell activation and inhibition of passive systemic …
Abstract tHGA, a geranyl acetophenone compound originally isolated from a local shrub
called Melicope ptelefolia, has been previously reported to prevent ovalbumin-induced …
called Melicope ptelefolia, has been previously reported to prevent ovalbumin-induced …
Synthesis and docking studies of 2, 4, 6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor
The natural product molecule 2, 4, 6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated
from the medicinal plant Melicope ptel efolia was shown to exhibit potent lipoxygenase …
from the medicinal plant Melicope ptel efolia was shown to exhibit potent lipoxygenase …
Blockade of eosinophil-induced bronchial epithelial-mesenchymal transition with a geranyl acetophenone in a coculture model
Epithelial-mesenchymal transition (EMT) is currently recognized as the main cellular event
that contributes to airway remodeling. Eosinophils can induce EMT in airway epithelial cells …
that contributes to airway remodeling. Eosinophils can induce EMT in airway epithelial cells …
A Synthetic Curcuminoid Analogue, 2, 6‐Bis‐4‐(Hydroxyl‐3‐Methoxybenzylidine)‐Cyclohexanone (BHMC) Ameliorates Acute Airway Inflammation of Allergic Asthma …
2, 6‐Bis‐(4‐hydroxyl‐3‐methoxybenzylidine) cyclohexanone (BHMC), a synthetic
curcuminoid analogue, has been shown to exhibit anti‐inflammatory properties in cellular …
curcuminoid analogue, has been shown to exhibit anti‐inflammatory properties in cellular …
Barrier protective effects of 2, 4, 6-trihydroxy-3-geranyl acetophenone on lipopolysaccharides-stimulated inflammatory responses in human umbilical vein endothelial …
Abstract Pharmocological relevance 2, 4, 6-trihydroxy-3-geranyl acetophenone (tHGA), is a
phloroglucinol compound found naturally in Melicope ptelefolia. Melicope ptelefolia has …
phloroglucinol compound found naturally in Melicope ptelefolia. Melicope ptelefolia has …
An orally active geranyl acetophenone attenuates airway remodeling in a murine model of chronic asthma
Abstract 2, 4, 6-Trihydroxy-3-geranyl acetophenone (tHGA) is a synthetic compound that is
naturally found in Melicope ptelefolia. We had previously demonstrated that parenteral …
naturally found in Melicope ptelefolia. We had previously demonstrated that parenteral …