The cellular and physiological basis for lung repair and regeneration: past, present, and future

MC Basil, J Katzen, AE Engler, M Guo, MJ Herriges… - Cell stem cell, 2020 - cell.com
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

[HTML][HTML] Developments in lung transplantation over the past decade

SC van der Mark, RAS Hoek… - European Respiratory …, 2020 - Eur Respiratory Soc
With an improved median survival of 6.2 years, lung transplantation has become an
increasingly acceptable treatment option for end-stage lung disease. Besides survival …

Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant: the OCS liver PROTECT randomized clinical trial

JF Markmann, MS Abouljoud, RM Ghobrial… - JAMA …, 2022 - jamanetwork.com
Importance Ischemic cold storage (ICS) of livers for transplant is associated with serious
posttransplant complications and underuse of liver allografts. Objective To determine …

Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment―A consensus report from the Pulmonary Council of the ISHLT

GM Verleden, AR Glanville, ED Lease… - The Journal of Heart …, 2019 - jhltonline.org
The outcomes of transplantation vary widely by organ. Lung transplantation (LTx) has rather
poor long-term outcome, with a current median post-transplant survival of 6.0 years. 1, 2 …

[HTML][HTML] Bilateral lung transplantation on intraoperative extracorporeal membrane oxygenator: an observational study

K Hoetzenecker, A Benazzo, T Stork, K Sinn… - The Journal of thoracic …, 2020 - Elsevier
Objective Intraoperative extracorporeal membrane oxygenation (ECMO) is usually reserved
to support patients during complex lung transplantation. We hypothesized that a routine …

Partial freezing of rat livers extends preservation time by 5-fold

SN Tessier, RJ de Vries, CA Pendexter… - Nature …, 2022 - nature.com
The limited preservation duration of organs has contributed to the shortage of organs for
transplantation. Recently, a tripling of the storage duration was achieved with supercooling …

[HTML][HTML] Ex vivo lung perfusion

T Watanabe, M Cypel, S Keshavjee - Journal of thoracic disease, 2021 - ncbi.nlm.nih.gov
Lung transplantation is a life-saving treatment for patients with end stage lung disease. The
imbalance between lung graft supply and recipients has been a serious issue and barrier to …

Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs

AE Hozain, JD O'Neill, MR Pinezich, Y Tipograf… - Nature medicine, 2020 - nature.com
Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the
use of most donor lungs. Although ex vivo lung perfusion (EVLP) is able to recover marginal …

Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended …

G Loor, G Warnecke, MA Villavicencio… - The Lancet …, 2019 - thelancet.com
Background Donor lung use for transplantation is the lowest among solid organ tranplants
because of several complex and multifactorial reasons; one area that could have a …

Design, analysis, and pitfalls of clinical trials using ex situ liver machine perfusion: the international liver transplantation society consensus guidelines

PN Martins, MD Rizzari, D Ghinolfi, I Jochmans… - …, 2021 - journals.lww.com
Design, Analysis, and Pitfalls of Clinical Trials Using Ex S... : Transplantation Design, Analysis,
and Pitfalls of Clinical Trials Using Ex Situ Liver Machine Perfusion: The International Liver …