Epithelial cell adhesion molecule: an anchor to isolate clinically relevant circulating tumor cells

In the last few decades, the epithelial cell adhesion molecule (EpCAM) has received
increased attention as the main membrane marker used in many enrichment technologies to …

Revisiting the roles of pro-metastatic EpCAM in cancer

MA Mohtar, SE Syafruddin, SN Nasir, TY Low - Biomolecules, 2020 - mdpi.com
Epithelial cell adhesion molecule (EpCAM) is a cell surface protein that was discovered as a
tumour marker of epithelial origins nearly four decades ago. EpCAM is expressed at basal …

Circ_0058106 promotes proliferation, metastasis and EMT process by regulating Wnt2b/β-catenin/c-Myc pathway through miR-185-3p in hypopharyngeal squamous …

C Li, W Li, S Cao, J Xu, Y Qian, X Pan, D Lei… - Cell death & …, 2021 - nature.com
Hypopharyngeal squamous cell carcinoma (HSCC) accounts 95% of hypopharyngeal
cancer, which is characterized by high early metastasis rate and poor prognosis. It is …

Syndecan-1 suppresses cell growth and migration via blocking JAK1/STAT3 and Ras/Raf/MEK/ERK pathways in human colorectal carcinoma cells

S Wang, X Zhang, G Wang, B Cao, H Yang, L Jin… - BMC cancer, 2019 - Springer
Abstract Background Syndecan-1 (SDC-1) is a crucial membrane proteoglycan, which is
confirmed to participate in several tumor cell biological processes. However, the biological …

Anti-cancer therapeutic strategies based on HGF/MET, EpCAM, and tumor-stromal cross talk

K Barzaman, R Vafaei, M Samadi, MH Kazemi… - Cancer Cell …, 2022 - Springer
As an intelligent disease, tumors apply several pathways to evade the immune system. It can
use alternative routes to bypass intracellular signaling pathways, such as nuclear factor-κB …

Transcription factor FoxM1 is the downstream target of c-Myc and contributes to the development of prostate cancer

H Pan, Y Zhu, W Wei, S Shao, X Rui - World journal of surgical oncology, 2018 - Springer
Background Prostate cancer is a common malignancy and the second leading cause of
cancer death in men. Elevated expression of the transcription factor FoxM1 and c-Myc has …

Reconstituting immune surveillance in breast cancer: Molecular pathophysiology and current immunotherapy strategies

C Cilibrasi, P Papanastasopoulos, M Samuels… - International journal of …, 2021 - mdpi.com
Over the past 50 years, breast cancer immunotherapy has emerged as an active field of
research, generating novel, targeted treatments for the disease. Immunotherapies carry …

[HTML][HTML] Immunotherapy in breast cancer: A clinician's perspective

S Chaudhuri, S Thomas, P Munster - Journal of the National Cancer Center, 2021 - Elsevier
Globally over 2 million women are diagnosed with breast cancer each year despite major
advances in detection and treatment of the disease. Breast cancer is comprised of several …

EpCAM duality becomes this molecule in a new Dr. Jekyll and Mr. Hyde tale

A Herreros-Pomares, C Aguilar-Gallardo… - Critical Reviews in …, 2018 - Elsevier
EpCAM, known as an epithelial cell adhesion molecule, plays an essential role in cell
adhesion, migration, metastasis and cell signalling. Rather than acting as an apoptosis …

Integrated analysis of mRNA-miRNA expression in Tilapia infected with Tilapia lake virus (TiLV) and identifies primarily immuneresponse genes

Y Wang, Q Wang, Y Li, J Yin, Y Ren, C Shi… - Fish & shellfish …, 2020 - Elsevier
We investigated differential gene expression in Tilapia infected with the Tilapia Lake virus
(TiLV). We used high-throughput sequencing to identify mRNAs and miRNAs involved in …