Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell
growth and metabolism through the modulation of protein and lipid synthesis, lysosome …

Macroautophagy is a lysosomal degradative pathway or recycling process that maintains
cellular homeostasis. This autophagy involves a series of sequential processing events …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …

Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …

Summary Store-operated Ca 2+ entry (SOCE) is the main Ca 2+ influx pathway in
lymphocytes and is essential for T cell function and adaptive immunity. SOCE is mediated by …

Lysosomes are cell organelles that degrade macromolecules to recycle their components. If
lysosomal degradative function is impaired, eg, due to mutations in lysosomal enzymes or …

Lysosomes, the degradation center of the cell, are filled with acidic hydrolases. Lysosomes
generate nutrient-sensitive signals to regulate the import of H+, hydrolases, and endocytic …

TRPML3 is a Ca2+/Na+ release channel residing in both phagophores and endolysosomal
membranes. It is activated by PI3P and PI3, 5P2. Its activity can be enhanced by high …