Engineering the delivery system for CRISPR-based genome editing
Clustered regularly interspaced short palindromic repeat-CRISPR-associated protein
(CRISPR-Cas) systems, found in nature as microbial adaptive immune systems, have been …
(CRISPR-Cas) systems, found in nature as microbial adaptive immune systems, have been …
[HTML][HTML] Computational tools and resources supporting CRISPR-Cas experiments
P Sledzinski, M Nowaczyk, M Olejniczak - Cells, 2020 - mdpi.com
The CRISPR-Cas system has become a cutting-edge technology that revolutionized
genome engineering. The use of Cas9 nuclease is currently the method of choice in most …
genome engineering. The use of Cas9 nuclease is currently the method of choice in most …
[HTML][HTML] De novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy
K Nakamura, H Kodera, T Akita, M Shiina… - The American Journal of …, 2013 - cell.com
Heterotrimeric G proteins, composed of α, β, and γ subunits, can transduce a variety of
signals from seven-transmembrane-type receptors to intracellular effectors. By whole-exome …
signals from seven-transmembrane-type receptors to intracellular effectors. By whole-exome …
[HTML][HTML] Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages
H Moradian, T Roch, L Anthofer, A Lendlein… - … Therapy-Nucleic Acids, 2022 - cell.com
In vitro transcribed (IVT)-mRNA has been accepted as a promising therapeutic modality.
Advances in facile and rapid production technologies make IVT-mRNA an appealing …
Advances in facile and rapid production technologies make IVT-mRNA an appealing …
Electrospun fiber-mediated delivery of neurotrophin-3 mRNA for neural tissue engineering applications
Aligned electrospun fibers provide topographical cues and local therapeutic delivery to
facilitate robust peripheral nerve regeneration. mRNA delivery enables transient expression …
facilitate robust peripheral nerve regeneration. mRNA delivery enables transient expression …
MRNA therapy for Fabry disease
BC Guild, F DeRosa, M Heartlein - US Patent 9,308,281, 2016 - Google Patents
US9308281B2 - MRNA therapy for Fabry disease - Google Patents US9308281B2 - MRNA
therapy for Fabry disease - Google Patents MRNA therapy for Fabry disease Download PDF …
therapy for Fabry disease - Google Patents MRNA therapy for Fabry disease Download PDF …
[HTML][HTML] mRNA transfection-induced activation of primary human monocytes and macrophages: dependence on carrier system and nucleotide modification
Monocytes and macrophages are key players in maintaining immune homeostasis.
Identifying strategies to manipulate their functions via gene delivery is thus of great interest …
Identifying strategies to manipulate their functions via gene delivery is thus of great interest …
Material design for next-generation mrna vaccines using lipid nanoparticles
Vaccine development is among the critical issues for ceasing the COVID-19 pandemic. This
review discusses the current usage of biomaterials in vaccine development and provides …
review discusses the current usage of biomaterials in vaccine development and provides …
Paving the way towards precise and safe CRISPR genome editing
P Sledzinski, M Dabrowska, M Nowaczyk… - Biotechnology …, 2021 - Elsevier
As the possibilities of CRISPR-Cas9 technology have been revealed, we have entered a
new era of research aimed at increasing its specificity and safety. This stage of technology …
new era of research aimed at increasing its specificity and safety. This stage of technology …
Improved CaP Nanoparticles for Nucleic Acid and Protein Delivery to Neural Primary Cultures and Stem Cells
Efficiently delivering exogenous materials into primary neurons and neural stem cells
(NSCs) has long been a challenge in neurobiology. Existing methods have struggled with …
(NSCs) has long been a challenge in neurobiology. Existing methods have struggled with …