The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …

The Precision Neurology development process implements systems theory with system
biology and neurophysiology in a parallel, bidirectional research path: a combined …

Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's
diseases), and of malignancy (cancers) have complex and varied causative factors. Modern …

The discovery of bioactive molecules is an expensive and time-consuming process and new
strategies are continuously searched for in order to optimize this process. Virtual Screening …

CNS disorders, and in particular psychiatric illnesses, lack definitive disease-altering
therapeutics. The limited understanding of the mechanisms driving these illnesses with the …

Background Alzheimer's disease (AD) is the most prevalent form of dementia and represents
one of the highest unmet requirements in medicine today. There is shortage of novel …

Polypharmacology is nowadays considered an increasingly crucial aspect in discovering
new drugs as a number of original single-target drugs have been performing far behind …

Urtica dioica is a perennial herb from the family of Urticaceae that is commonly known as
stinging nettle. This plant is widespread in Europe, Africa, America, and a part of Asia, as it …

Monoamine oxidases (MAOs) catalyse the oxidation of neurotransmitter amines and a wide
variety of primary, secondary and tertiary amine xenobiotics, including therapeutic drugs …

A large body of experimental and clinical evidence has strongly suggested that monoamines
play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and …