Sixty years ago Carl Martius (1906-1993), then “Wissenschaftlicher Assistent” to Franz
Knoop at the Biochemical Institute of the University of Tubingen, did an experiment, crucial …

NAD (P)+-dependent dehydrogenases comprise a substantial and diverse group of proteins
differing in structure and function. They catalyse a number of key metabolic steps and …

Formation of a short (less than 2.5 angstroms), very strong, low-barrier hydrogen bond in the
transition state, or in an enzyme-intermediate complex, can be an important contribution to …

Malate dehydrogenases are widely distributed and alignment of the amino acid sequences
show that the enzyme has diverged into 2 main phylogenetic groups. Multiple amino acid …

Three variations to the structure of the nicotinamide adenine dinucleotide (NAD)-dependent
L-lactate dehydrogenase from Bacillus stearothermophilus were made to try to change the …

The crystal structure of flavocytochrome b 2 has been solved at 3.0 Å resolution by the
method of multiple isomorphous replacement with anomalous scattering. Area detector data …

Soon after the introduction of electrophoretic techniques to study the genetic structure of
natural populations of animals and plants came the realization that enzymes differed in their …

The crystal structure of the phosphoglycerate dehydrogenase from Eschehchia coli is
unique among dehydrogenases. It consists of three clearly separate domains connected by …

We present an approach that is able to detect native folds amongst a large number of non-
native conformations. The method is based on the compilation of potentials of mean force of …

Three-dimensional crystal structures of holo (ternary complex enzyme-NAD-azide) and apo
NAD-dependent dimeric formate dehydrogenase (FDH) from the methylotrophic bacterium …