Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and
progression. In this review, we update currents concepts of hypoxia-induced alternative …

Hypoxia is dangerous for oxygen-dependent cells, therefore, physiological adaption to
cellular hypoxic conditions is essential. The transcription factor hypoxia-inducible factor …

Unlike solid organs, human airway epithelia derive their oxygen from inspired air rather than
the vasculature. Many pulmonary diseases are associated with intraluminal airway …

Hypoxia, a characteristic of the tumour microenvironment, plays a crucial role in cancer
progression and therapeutic response. The hypoxia-inducible factors (HIF-1α, HIF-2α, and …

Identification of pro-metastatic genomic alterations is urgently needed to help understand
and prevent the fatal course of prostate cancer. Here, we found that the transcription factor …

Hypoxia triggers complex inter-and intracellular signals that regulate tissue oxygen (O2)
homeostasis, adjusting convective O2 delivery and utilization (ie, metabolism). Human …

Maintenance of oxygen homeostasis is an indispensable criterion for the existence of
multicellular life-forms. Disruption of this homeostasis due to inadequate oxygenation of the …

Pediatric neuroblastomas (NBs) are heterogeneous, aggressive, therapy-resistant
embryonal tumours that originate from cells of neural crest (NC) origin and in particular …

Hypoxia-inducible factors (HIFs) regulate cellular oxygen balance and play a central role in
cancer metastasis and angiogenesis. Despite extensive research on HIFs, successful …

In multicellular organisms, alternative splicing (AS) is central to the regulation of multiple
biological processes. To further elucidate the adaptive strategy of AS in the lungs of Tibetan …