Sleep· 2: Pathophysiology of obstructive sleep apnoea/hypopnoea syndrome

RB Fogel, A Malhotra, DP White - Thorax, 2004 - thorax.bmj.com
The pathogenesis of airway obstruction in patients with obstructive sleep
apnoea/hypopnoea syndrome is reviewed. The primary defect is probably an anatomically …

Obstructive sleep apnea

DP White, MK Younes - Comprehensive Physiology, 2012 - Wiley Online Library
Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive collapse of
the pharyngeal airway during sleep. Control of pharyngeal patency is a complex process …

Upper airway and soft tissue anatomy in normal subjects and patients with sleep-disordered breathing. Significance of the lateral pharyngeal walls.

RJ Schwab, KB Gupta, WB Gefter… - American journal of …, 1995 - atsjournals.org
The geometry and caliber of the upper airway in apneic patients differs from those in normal
subjects. The apneic airway is smaller and is narrowed laterally. Examination of the soft …

Upper airway muscle inflammation and denervation changes in obstructive sleep apnea

JH Boyd, BJ Petrof, Q Hamid, R Fraser… - American journal of …, 2004 - atsjournals.org
Inflammatory cell infiltration and afferent neuropathy have been shown in the upper airway
(UA) mucosa of subjects with obstructive sleep apnea (OSA). We hypothesized that …

Histological indications of a progressive snorers disease in an upper airway muscle

D Friberg, TOR Ansved, K Borg… - American journal of …, 1998 - atsjournals.org
The etiology of upper airway collapsibility in patients with snoring and obstructive sleep
apnea (OSA) remains unclear. Local muscular abnormalities, including neurogenic lesions …

The hypotonic upper airway in obstructive sleep apnea: role of structures and neuromuscular activity

AR Schwartz, CP O'DONNELL, J Baron… - American journal of …, 1998 - atsjournals.org
The structural properties of the upper airway determine its collapsibility during periods of
muscle hypotonia. Both rapid-eye-movement (REM) sleep and increases in nasal pressure …

Patients with obstructive sleep apnea exhibit genioglossus dysfunction that is normalized after treatment with continuous positive airway pressure

M Carrera, F Barbe, J Sauleda, M Tomas… - American journal of …, 1999 - atsjournals.org
Obstructive sleep apnea syndrome (OSAS) is characterized by repetitive episodes of
pharyngeal closure during sleep. The pathogenesis of OSAS is unclear. We hypothesized …

Physiologic, metabolic, and muscle fiber type characteristics of musculus uvulae in sleep apnea hypopnea syndrome and in snorers.

F Series, C Cote, JA Simoneau… - The Journal of …, 1995 - Am Soc Clin Investig
Upper airway dilator muscles play an important role in the pathophysiology of sleep apnea
hypopnea syndrome (SAHS). The mechanical and structural characteristics of these …

[PDF][PDF] Tongue-muscle training by intraoral electrical neurostimulation in patients with obstructive sleep apnea

WJ Randerath, W Galetke, U Domanski, R Weitkunat… - Sleep, 2004 - researchgate.net
Study objectives: To investigate the efficacy of tongue-muscle training by electrical
neurostimulation of the upper-airway muscles as an alternative therapy option for obstructive …

Evaluation of arterial blood gases and arterial blood pressures in brachycephalic dogs

GL Hoareau, G Jourdan, M Mellema… - Journal of Veterinary …, 2012 - Wiley Online Library
Background Brachycephalic dogs (BD) are prone to congenital upper airway obstruction
(brachycephalic syndrome, BS). In humans suffering from sleep apnea, upper airway …