[HTML][HTML] Enterovirus A71 antivirals: past, present, and future

J Wang, Y Hu, M Zheng - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Abstract Enterovirus A71 (EV-A71) is a significant human pathogen, especially in children.
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …

[HTML][HTML] Lycorine: A prospective natural lead for anticancer drug discovery

M Roy, L Liang, X Xiao, P Feng, M Ye, J Liu - Biomedicine & …, 2018 - Elsevier
Nature is the most abundant source for novel drug discovery. Lycorine is a natural alkaloid
with immense therapeutic potential. Lycorine is active in a very low concentration and with …

High-throughput screening and identification of potent broad-spectrum inhibitors of coronaviruses

L Shen, J Niu, C Wang, B Huang, W Wang… - Journal of …, 2019 - Am Soc Microbiol
Coronaviruses (CoVs) act as cross-species viruses and have the potential to spread rapidly
into new host species and cause epidemic diseases. Despite the severe public health threat …

A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors

P Ren, W Shang, W Yin, H Ge, L Wang… - Acta Pharmacologica …, 2022 - nature.com
The COVID-19, caused by SARS-CoV-2, is threatening public health, and there is no
effective treatment. In this study, we have implemented a multi-targeted anti-viral drug …

Viral proteases: Structure, mechanism and inhibition

J Zephyr, NK Yilmaz, CA Schiffer - The enzymes, 2021 - Elsevier
Viral proteases are diverse in structure, oligomeric state, catalytic mechanism, and substrate
specificity. This chapter focuses on proteases from viruses that are relevant to human health …

Antiviral activity of lycorine against Zika virus in vivo and in vitro

H Chen, Z Lao, J Xu, Z Li, H Long, D Li, L Lin, X Liu… - Virology, 2020 - Elsevier
The emergence and re-emergence of Zika virus (ZIKV), is a cause for international concern.
These highly pathogenic arboviruses represent a serious health burden in tropical and …

Enteroviruses: classification, diseases they cause, and approaches to development of antiviral drugs

OS Nikonov, ES Chernykh, MB Garber… - Biochemistry (moscow …, 2017 - Springer
The genus Enterovirus combines a portion of small (+) ssRNA-containing viruses and is
divided into 10 species of true enteroviruses and three species of rhinoviruses. These …

Antiviral alkaloid principles of the plant family Amaryllidaceae

JJ Nair, J van Staden - Phytomedicine, 2023 - Elsevier
Background Viral-borne diseases are amongst the oldest diseases known to mankind. They
are responsible for some of the most ravaging effects wrought on human health and well …

Lycorine and organ protection: Review of its potential effects and molecular mechanisms

H Xiao, X Xu, L Du, X Li, H Zhao, Z Wang, L Zhao… - Phytomedicine, 2022 - Elsevier
Background Multiorgan dysfunction, especially sepsis-related multiorgan damage, remains
a major cause of high mortality in the late stages of infection and a great clinical challenge …

Amaryllidaceae and Sceletium alkaloids

Z Jin, G Yao - Natural Product Reports, 2019 - pubs.rsc.org
Covering: July 2015 to June 2017. Previous review: Nat. Prod. Rep., 2016, 33, 1318–1343
Recent progress on the isolation, identification, biological activity and synthetic studies of the …