Glycosaminoglycans (GAGs) as one major part of the glycocalyx are involved in many
essential biological cell processes, as well as in many courses of diseases. Because of the …

Cyclodextrins are widely used as carriers of small molecules for drug delivery owing to their
remarkable host properties and excellent biocompatibility. However, cyclic oligosaccharides …

The enzyme heparanase, an endo-β-glucuronidase, degrades heparan sulfate (HS) chains
on the cell surface and in the extracellular matrix. Heparanase regulates numerous …

Here, we disclosed a convenient procedure for the preparation of EPP [3, 5-dimethyl-4-(2′-
phenylethynylphenyl) phenyl] glycosides and their application to an effective synthesis of …

The anomeric configuration can greatly affect the biological functions and activities of
carbohydrates. Herein, we report that N‐phenyltrifluoroacetimidoyl (PTFAI), a well‐known …

Amyloid fibrils represent a pathological state of protein polymer that is closely associated
with various neurodegenerative diseases. Polysaccharides have a prominent role in …

On account of the challenge of discriminating glycosaminoglycans (GAGs) via optical
methods, we designed a fluorescence displacement sensing array. The sensing array is …

The human natural killer-1 (HNK-1) epitope is a unique sulfated trisaccharide sequence
presented on O-and N-glycans of various glycoproteins and on glycolipids. It is …

Highlights•Heparin and heparan sulfate binds various proteins and modulate their
activity.•Advances allowed the chemical preparation of long sugars and sugar libraries.• …

The practical formal synthesis of the anticoagulant drug fondaparinux sodium 1 was
accomplished using an optimized modular synthetic strategy. The important …