Fibro-adipogenic progenitors (FAPs) are key regulators of skeletal muscle regeneration and
homeostasis. However, dysregulation of these cells leads to fibro-fatty infiltration across …

Fibrosis is defined by the excessive accumulation of extracellular matrix (ECM) and
constitutes a central pathophysiological process that underlies tissue dysfunction, across …

Abstract Background and Aims Valve interstitial cells (VICs) undergo a transition to
intermediate state cells before ultimately transforming into the osteogenic cell population …

Heart failure (HF) is a leading cause of morbidity and mortality particularly in older adults
and patients with multiple metabolic comorbidities. Heart failure with preserved ejection …

In the last years, major progress has occurred in heart failure (HF) management. The 2023
ESC focused update of the 2021 HF guidelines introduced new key recommendations …

Background Hypertrophic cardiomyopathy (HCM) is a genetic disorder characterized by left
ventricular hypertrophy that can lead to heart failure, arrhythmias, and sudden cardiac death …

Virtually all forms of cardiac disease exhibit cardiac fibrosis as a common trait, which
ultimately leads to adverse ventricular remodeling and heart failure. To improve the …

Objective The transcriptional heterogeneity at a single‐nucleus level in human Becker
muscular dystrophy (BMD) dystrophic muscle has not been explored. Here, we aimed to …

Heart failure is a significant health issue in developed countries, often stemming from
conditions like hypertension, which imposes a pressure overload on the heart. Despite …

Skin photoaging induced by ultraviolet (UV) irradiation contributes to the formation of thick
and coarse wrinkles. Humans are exposed to UV light throughout their lives. Therefore, it is …